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Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age
- Source :
- Cells, Cells, Vol 9, Iss 2, p 266 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Transcription of the ribosomal RNA genes (rDNA) that encode the three largest ribosomal RNAs (rRNA), is mediated by RNA Polymerase I (Pol I) and is a key regulatory step for ribosomal biogenesis. Although it has been reported over a century ago that the number and size of nucleoli, the site of ribosome biogenesis, are increased in cancer cells, the significance of this observation for cancer etiology was not understood. The realization that the increase in rRNA expression has an active role in cancer progression, not only through increased protein synthesis and thus proliferative capacity but also through control of cellular check points and chromatin structure, has opened up new therapeutic avenues for the treatment of cancer through direct targeting of Pol I transcription. In this review, we discuss the rational of targeting Pol I transcription for the treatment of cancer; review the current cancer therapeutics that target Pol I transcription and discuss the development of novel Pol I-specific inhibitors, their therapeutic potential, challenges and future prospects.
- Subjects :
- Transcription, Genetic
Nucleolus
Ribosome biogenesis
ribosome biogenesis
Review
Biology
03 medical and health sciences
0302 clinical medicine
Transcription (biology)
RNA Polymerase I
Neoplasms
RNA polymerase I
CX-5461
Humans
lcsh:QH301-705.5
030304 developmental biology
0303 health sciences
General Medicine
Ribosomal RNA
3. Good health
Chromatin
Cell biology
lcsh:Biology (General)
Patient Satisfaction
030220 oncology & carcinogenesis
RNA polymerase I transcription
Drug Design
Cancer cell
cancer therapy
Ribosomes
Biogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 9
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....2e5b2b2ecec85c58dc41308766979133