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Neurofibrillary Tangles and Conversion to Mild Cognitive Impairment with Certain Antihypertensives
- Source :
- J Alzheimers Dis
- Publication Year :
- 2019
-
Abstract
- BACKGROUND: Individuals taking renin angiotensin system (RAS) acting antihypertensives exhibit slower cognitive decline and are less likely to progress from mild cognitive impairment (MCI) to Alzheimer’s disease (AD), but the mechanism remains unclear. OBJECTIVE: We tested the hypothesis that individuals taking RAS acting antihypertensives exhibit less AD-related neuropathology and slower disease progression than individuals taking non-RAS acting antihypertensives. METHOD: Participants included 83 individuals with MCI who were taking an antihypertensive at baseline, had at least two follow-up visits, and had postmortem neuropathological data. Participants were old (M = 83.1 years), 32% male, well educated (M = 15.7 years), and 9.2% Black. RESULTS: RAS medication users (N = 38) were less likely to progress to AD than non-RAS users (N = 45). RAS users exhibited fewer neurofibrillary tangles than non-RAS users in the hippocampal CA1 region (p < 0.01), entorhinal cortex (p = 0.03), and the angular gyrus, inferior temporal, mid-frontal cortex, and superior frontal (p = 0.01). CONCLUSION: Prevention or clearance of neurofibrillary tangles represents a mechanism by which RAS medications may slow disease progression.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Neuropathology
Disease
Hippocampal formation
Article
Angular gyrus
Renin-Angiotensin System
03 medical and health sciences
0302 clinical medicine
Cognition
Alzheimer Disease
Internal medicine
Medicine
Humans
Cognitive Dysfunction
Cognitive decline
Cognitive impairment
Antihypertensive Agents
Aged
Aged, 80 and over
business.industry
General Neuroscience
Brain
Neurofibrillary Tangles
General Medicine
Entorhinal cortex
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Blood pressure
Hypertension
Disease Progression
Female
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 70
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....2e518ea89470e4363c4ac5a766c760bf