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A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus
- Source :
- Nature immunology, vol 16, iss 2
- Publication Year :
- 2014
-
Abstract
- Dengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope (EDE), that bridges two envelope protein subunits that make up the 90 repeating dimers on the mature virion. The mAbs to EDE were broadly reactive across the dengue serocomplex and fully neutralized virus produced in either insect cells or primary human cells, with 50% neutralization in the low picomolar range. Our results provide a path to a subunit vaccine against dengue virus and have implications for the design and monitoring of future vaccine trials in which the induction of antibody to the EDE should be prioritized.
- Subjects :
- TICK-BORNE ENCEPHALITIS
Dengue virus
medicine.disease_cause
Epitope
Neutralization
Dengue fever
Dengue
Viral Envelope Proteins
Monoclonal
Immunology and Allergy
IMMUNE-RESPONSE
Neutralizing
Antibodies, Monoclonal
ENVELOPE GLYCOPROTEIN
FUSION-LOOP
Infectious Diseases
1107 Immunology
Biological Assay
Antibody
Infection
Life Sciences & Biomedicine
Biotechnology
medicine.drug_class
Immunology
Immunoblotting
Enzyme-Linked Immunosorbent Assay
Biology
MEMBRANE-FUSION
Monoclonal antibody
Virus
Antibodies
Article
MATURATION
Cell Line
Vaccine Related
Rare Diseases
Immunity
Biodefense
medicine
Animals
Humans
Science & Technology
Prevention
HUMAN MONOCLONAL-ANTIBODIES
Dengue Virus
medicine.disease
Virology
Antibodies, Neutralizing
Vector-Borne Diseases
Emerging Infectious Diseases
Good Health and Well Being
HEMORRHAGIC-FEVER
biology.protein
T-CELLS
Immunization
STRUCTURAL-CHANGES
Subjects
Details
- Language :
- English
- ISSN :
- 15292916 and 15292908
- Volume :
- 16
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Nature Immunology
- Accession number :
- edsair.doi.dedup.....2e4f7ce2a5021b95cb8a3f0f26277baf