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Antigen presenting cells and HLA-G – a review
- Source :
- Placenta. 26:S104-S109
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Maternal antigen presenting cells, which are macrophages and dendritic cells, are scattered throughout human decidualized endometrium during all stages of pregnancy. These powerful, multi-functional leukocytes reside in close proximity to uterine glandular epithelium, uterine blood vessels, and HLA-G-producing invasive cytotrophoblast cells. Macrophages and dendritic cells, which express the HLA-G receptors, ILT2 and ILT4, play major roles in driving innate and adaptive immune responses, altering the behavior of local stromal cells, shaping the cytokine microenvironment, and protecting the tissue from infection. Therefore, encounters between decidual antigen presenting cells and HLA-G molecules are likely to influence uterine and placental homeostasis as well as local maternal immune responses to the fetus during pregnancy.
- Subjects :
- Stromal cell
Antigen presentation
Antigen-Presenting Cells
Apoptosis
HLA Antigens
Pregnancy
Decidua
Immune Tolerance
Humans
Receptors, Immunologic
Antigen-presenting cell
Maternal-Fetal Exchange
HLA-G Antigens
Innate immune system
CD40
Follicular dendritic cells
biology
Macrophages
Histocompatibility Antigens Class I
Models, Immunological
Obstetrics and Gynecology
Dendritic Cells
Dendritic cell
B-1 cell
Phenotype
Reproductive Medicine
Immunology
biology.protein
Cytokines
Female
Developmental Biology
Subjects
Details
- ISSN :
- 01434004
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Placenta
- Accession number :
- edsair.doi.dedup.....2e486891fedcc4020c7e017a25d75000