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Systemic biomarkers of inflammation, oxidative stress and tissue injury and repair among waterpipe, cigarette and dual tobacco smokers
- Source :
- Tob Control
- Publication Year :
- 2019
- Publisher :
- BMJ, 2019.
-
Abstract
- BackgroundWaterpipe tobacco (WPT) smoking is associated with deleterious effects on cardio-pulmonary systems which may have adverse repercussions in pathophysiology and progression of chronic lung and cardiovascular diseases. We compared the biomarkers of systemic inflammation, lipid mediators, injury/repair and oxidative stress between groups of non-smokers (NS), exclusive WPT smokers (WPS), exclusive cigarette smokers (CS) and dual WPS and CS (DS).MethodsTwo cohorts were recruited. Cohort I consisted of WPS (n=12), CS (n=26), DS (n=10) and NS (n=25). Cohort II consisted of WPS (n=33) and NS (n=24). Plasma and urine samples were collected and analysed for various systemic biomarkers.ResultsCompared with NS, plasma levels of inflammatory mediators (interleukin (IL)-6, IL-8, IL1β and tumor necrosis factor-α) were significantly higher in WPS and CS, and were further augmented in DS. Endothelial biomarkers (intracellular adhesion molecule-1, prostaglandin E-2 and metalloproteinase-9) were significantly higher in CS. Most notably, pro-resolving lipid mediator (resolvin E1) and biomarkers of immunity, tissue injury, and repair were significantly lower in WPS and CS. Urinary levels of 8-isoprostane were significantly higher in all smoking groups in cohort I, while 8-isoprostane, myeloperoxidase, receptor for advanced glycation end products (RAGE), En-RAGE and matrix metalloproteinase-9 were significantly higher in all smoking groups in cohort II.ConclusionsBiomarkers of inflammation, oxidative stress, immunity, tissue injury and repair were elevated in WPS and CS groups. Furthermore, concurrent use of WPT and cigarettes is more harmful than cigarette or WPT smoking alone. These data may help inform the public and policy-makers about the dangers of WPT smoking and dual use of tobacco products.
- Subjects :
- Adult
Male
medicine.medical_specialty
Health (social science)
Water Pipe Smoking
Inflammation
medicine.disease_cause
Systemic inflammation
Gastroenterology
Article
Cigarette Smoking
Cohort Studies
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
030304 developmental biology
0303 health sciences
Smokers
biology
business.industry
Public Health, Environmental and Occupational Health
Interleukin
Non-Smokers
030206 dentistry
Middle Aged
Pathophysiology
Oxidative Stress
Cross-Sectional Studies
Myeloperoxidase
Cohort
biology.protein
Female
Tumor necrosis factor alpha
Inflammation Mediators
medicine.symptom
business
Biomarkers
Oxidative stress
Subjects
Details
- ISSN :
- 14683318 and 09644563
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Tobacco Control
- Accession number :
- edsair.doi.dedup.....2e3c0b8565c75c2eb4cdb5baea2a0518