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Outcomes of Japanese patients with non-alcoholic fatty liver disease according to genetic background and lifestyle-related diseases
- Source :
- Annals of Hepatology, Vol 21, Iss, Pp 100260-(2021)
- Publication Year :
- 2020
-
Abstract
- Introduction and objectives Genetic background may be involved in the mechanisms of liver injury and the development of non-alcoholic fatty liver disease (NAFLD). However, its contributions to the long-term outcome of NAFLD have been unclear. Methods We enrolled 314 Japanese patients with biopsy-confirmed NAFLD from 2000 to 2018 (161 men [51.3%]; median age, 53 [14–84] years; 114 with advanced fibrosis [37.5%]) in the patients without hepatocellular carcinoma at diagnosis. Genomic DNA was extracted from peripheral blood and single nucleotide polymorphisms (SNPs) were analyzed. Associations of mortality with patatin-like phospholipase 3 (PNPLA3) and aldehyde dehydrogenase 2 (ALDH2) were analyzed. Finally, a subgroup analysis according to lifestyle-related disease was performed. Results During the median 7 years of follow-up, 20 patients (6.4%) died (13 liver-related [4.1%] and 7 non-liver-related deaths [2.2%]). Patients with ALDH2 (non-GG genotype) who had reduced alcohol metabolism tended to have a poor prognosis (p = 0.06). Patients carrying both risk SNPs of PNPLA3 (GG) and ALDH2 (non-GG) had a significantly poor prognosis (p = 0.01). In the subgroup analysis, patients with PNPLA3 (GG) who were non-diabetics (p = 0.06) or non-dyslipidemic (p = 0.03), with ALDH2 (non-GG) who were non-dyslipidemic (p = 0.01) or hypertensive (p = 0.03), also had a poor prognosis. The Cox analysis revealed that ALDH2 (non-GG) was associated with a poor prognosis (Hazard ratio: 4.568, 95% Confidence Interval: 1.294–16.131, p = 0.02) similar to the liver function tests. Conclusions Genetic background may affect NAFLD prognosis and ALDH2 SNP could predict the outcome.
- Subjects :
- Adult
Male
medicine.medical_specialty
Patatin-like phospholipase 3 (PNPLA3)
Adolescent
Genotype
Biopsy
Specialties of internal medicine
Single-nucleotide polymorphism
Subgroup analysis
Disease
Gastroenterology
Polymorphism, Single Nucleotide
Non-alcoholic fatty liver disease (NAFLD)
Young Adult
Japan
Single nucleotide polymorphism (SNP)
Non-alcoholic Fatty Liver Disease
Internal medicine
medicine
Humans
Mortality
Life Style
ALDH2
Aged
Aldehyde dehydrogenase 2 (ALDH2)
Aged, 80 and over
Hepatology
medicine.diagnostic_test
business.industry
Aldehyde Dehydrogenase, Mitochondrial
Hazard ratio
Fatty liver
General Medicine
DNA
Middle Aged
medicine.disease
RC581-951
Hepatocellular carcinoma
Female
Liver function tests
business
Genetic Background
Subjects
Details
- ISSN :
- 16652681
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Annals of hepatology
- Accession number :
- edsair.doi.dedup.....2e2a4f5276ee1a53e4ff04d2ee51477e