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Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, 2018, 19 (8), pp.2177. ⟨10.3390/ijms19082177⟩, International Journal of Molecular Sciences, MDPI, 2018, 19 (8), pp.2177. ⟨10.3390/ijms19082177⟩, International Journal of Molecular Sciences, Vol 19, Iss 8, p 2177 (2018)
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; A close relationship exists between cholesterol and female reproductive physiology. Indeed, cholesterol is crucial for steroid synthesis by ovary and placenta, and primordial for cell structure during folliculogenesis. Furthermore, oxysterols, cholesterol-derived ligands, play a potential role in oocyte maturation. Anomalies of cholesterol metabolism are frequently linked to infertility. However, little is known about the molecular mechanisms. In parallel, increasing evidence describing the biological roles of liver X receptors (LXRs) in the regulation of steroid synthesis and inflammation, two processes necessary for follicle maturation and ovulation. Both of the isoforms of LXRs and their bona fide ligands are present in the ovary. LXR-deficient mice develop late sterility due to abnormal oocyte maturation and increased oocyte atresia. These mice also have an ovarian hyper stimulation syndrome in response to gonadotropin stimulation. Hence, further studies are necessary to explore their specific roles in oocyte, granulosa, and theca cells. LXRs also modulate estrogen signaling and this could explain the putative protective role of the LXRs in breast cancer growth. Altogether, clinical studies would be important for determining the physiological relevance of LXRs in reproductive disorders in women
- Subjects :
- 0301 basic medicine
Placenta
Ovarian hyperstimulation syndrome
Review
lcsh:Chemistry
liver X receptors
Mice
0302 clinical medicine
Pregnancy
lcsh:QH301-705.5
Spectroscopy
media_common
Metabolic Syndrome
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
030219 obstetrics & reproductive medicine
Female infertility
General Medicine
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
3. Good health
Computer Science Applications
medicine.anatomical_structure
Theca
Female
female reproduction
Folliculogenesis
Infertility, Female
medicine.medical_specialty
media_common.quotation_subject
Breast Neoplasms
Ovary
[SDV.CAN]Life Sciences [q-bio]/Cancer
Biology
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Catalysis
Inorganic Chemistry
03 medical and health sciences
breast cancer
[SDV.CAN] Life Sciences [q-bio]/Cancer
Internal medicine
ovarian hyperstimulation syndrome
medicine
Animals
Humans
Obesity
Physical and Theoretical Chemistry
Liver X receptor
Molecular Biology
Ovulation
Organic Chemistry
cholesterol
Estrogens
medicine.disease
Oocyte
[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, 2018, 19 (8), pp.2177. ⟨10.3390/ijms19082177⟩, International Journal of Molecular Sciences, MDPI, 2018, 19 (8), pp.2177. ⟨10.3390/ijms19082177⟩, International Journal of Molecular Sciences, Vol 19, Iss 8, p 2177 (2018)
- Accession number :
- edsair.doi.dedup.....2e2263f995eb167189f8af78c5c606bf