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Useful Measurement of Glucose Variability by Flash Glucose Monitoring (FGM) with the Efficacy of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
- Source :
- SGLT2 inhibitors. 2:1-8
- Publication Year :
- 2020
- Publisher :
- Asploro Open Access Publications, 2020.
-
Abstract
- Diabetes has been a crucial medical and social problem worldwide. For adequate nutritional therapy, there have been discussions concerning Calorie Restriction (CR) and Low Carbohydrate Diet (LCD). We have investigated glucose variability of diabetic patients applying CR, LCD, continuous glucose monitoring (CGM) and applied FreeStyle Libre which is flash glucose monitoring (FGM). The patient is a 40-year-old female with type 2 diabetes mellitus (T2DM), who showed BMI 20.7, postprandial blood glucose 257 mg/dL. HbA1c 12.1%, Glycoalbumin 31.6% (11.6-16.4), serum C-peptide 2.0 ng/ml and unremarkable data of liver function, renal, lipids. She was provided the intervention of three stages, which are i) CR with 60% carbohydrate in Day 1-2, ii) LCD meal with 12% carbohydrate in Day 3-5; iii) LCD + Sodium-glucose cotransporter 2 (SGLT2) inhibitor (Ipragliflozin L-Proline 50mg) in Day 6-12. The glucose profile was measured by FreeStyle Libre Pro (Abbott) for 14 days. The daily profile of blood glucose was abruptly decreased on Day 6. Time percentage of satisfactory blood glucose 70-180 mg/dL (/24h) was 0%, 0%, 2%, 14%, 0%, 54%, 100% in Day 1-7, respectively. These results suppose the acute clinical efficacy of SGLT2 inhibitor, and this report would become a reference for future diabetic practice and research.
- Subjects :
- Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
medicine.medical_specialty
030209 endocrinology & metabolism
Flash Glucose Monitoring
Japan LCD Promotion Association (JLCDPA)
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Diabetes mellitus
Medicine
FreeStyle Libre Pro
business.industry
Type 2 Diabetes Mellitus
Carbohydrate
medicine.disease
Low Carbohydrate Diet
Ipragliflozin
Endocrinology
Postprandial
chemistry
Sodium/Glucose Cotransporter 2
Continuous Glucose Monitoring
Liver function
SGLT2 Inhibitor
business
Subjects
Details
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- SGLT2 inhibitors
- Accession number :
- edsair.doi.dedup.....2e16de055d4f714cb129d854d66d43eb