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Clinical outcomes and complications of fluid-filled scleral lens devices for the management of limbal stem cell deficiency
- Source :
- Cont Lens Anterior Eye, Contact lens & anterior eye : the journal of the British Contact Lens Association, vol 46, iss 1
- Publication Year :
- 2021
-
Abstract
- Aims To evaluate the clinical and visual outcomes of fluid-filled scleral lens devices (SL) wear in patients with limbal stem cell deficiency (LSCD). Design Retrospective consecutive case series. Methods 27 eyes with LSCD confirmed by in vivo confocal microscopy at the Stein Eye Institute and fitted with SL were included. Correlations between corrected distance visual acuity (CDVA) and LSCD stage determined by clinical grading were performed between baseline (after the SL fit) and the last follow-up (the time of discontinuation of SL wear or the last visit in eyes in which SL were continued). In a subset of patients that had worsened LSCD while using SL, anterior segment optical coherence tomography (AS-OCT) and anterior segment fluorescein angiogram (AS-FA) were performed. Results Baseline LSCD grading was stage I in 12 eyes (44.4%), stage 2 in 12 eyes (44.4%), and stage III in 3 eyes (11.1%). At the last follow-up, CDVA was improved in 7 eyes (25.9%), remained stable in 13 eyes (48.1%) and decreased in 7 eyes (25.9%, P = 0.16). The LSCD stage was improved in 7 eyes (25.9%), remained stable in 8 eyes (29.6%) and worsened in 12 eyes (44.4%, P = 0.10). AS-OCT and AS-FA, performed in 5 eyes, showed limbal compression and delayed fluorescein filling. Conclusion SL can improve visual acuity and maintain the ocular surface in the majority of eyes. Worsening of the ocular surface might be a result of limbal hypoxia. Close monitoring of SL fit is necessary in these compromised eyes.
- Subjects :
- In vivo confocal microscopy
medicine.medical_specialty
Visual acuity
Distance visual acuity
genetic structures
Scleral lens
Bioengineering
Limbus Corneae
tomography
Eye
Ophthalmology & Optometry
Article
Limbal stem cell deficiency
Corneal Diseases
Cornea
Anterior segment optical coherence tomography
Anterior segment fluorescein angiography
Clinical Research
Opthalmology and Optometry
Ophthalmology
medicine
Humans
PROSE lens
In patient
Stage (cooking)
Eye Disease and Disorders of Vision
Retrospective Studies
business.industry
Limbal Stem Cells
General Medicine
Limbal Stem Cell Deficiency
eye diseases
EyePrintPRO
medicine.anatomical_structure
Anterior segment optical coherence
Fluorescein
sense organs
medicine.symptom
business
Optometry
Subjects
Details
- ISSN :
- 14765411
- Database :
- OpenAIRE
- Journal :
- Contact lensanterior eye : the journal of the British Contact Lens Association
- Accession number :
- edsair.doi.dedup.....2e0d8752e99e6f210e5c989a70735020