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Prognostic indicators of survival in sinonasal extranodal natural killer/T‐cell lymphoma
- Source :
- The Laryngoscope. 129:2675-2680
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- OBJECTIVES Extranodal natural killer/T-cell lymphoma (ENKTL) is a highly aggressive tumor of the sinonasal tract associated with poor overall survival (OS). This study expands upon epidemiologic, prognostic, and treatment factors for OS and disease-specific survival (DSS), incorporating newly accessible chemotherapy data. METHODS Retrospective population-based cohort study performed on cases of sinonasal ENKTL identified through the Surveillance, Epidemiology, and End Results database. Univariate Kaplan-Meier analysis and subsequent multivariate Cox-regression analysis were performed to evaluate prognostic and treatment variables for OS and DSS. RESULTS Four hundred and sixty cases of sinonasal ENKTL were identified. Five-year OS and DSS were 46% and 56%, respectively. On multivariate analysis, higher Ann Arbor stage was associated with worse OS (P
- Subjects :
- Male
Oncology
medicine.medical_specialty
medicine.medical_treatment
Nose Neoplasms
Population
03 medical and health sciences
0302 clinical medicine
Internal medicine
Epidemiology
medicine
Humans
Stage (cooking)
education
Neoplasm Staging
Retrospective Studies
Chemotherapy
education.field_of_study
business.industry
Sinonasal Tract
Middle Aged
Prognosis
medicine.disease
Combined Modality Therapy
United States
Lymphoma
Lymphoma, Extranodal NK-T-Cell
Survival Rate
Radiation therapy
Otorhinolaryngology
030220 oncology & carcinogenesis
Female
business
030217 neurology & neurosurgery
Follow-Up Studies
SEER Program
Cohort study
Subjects
Details
- ISSN :
- 15314995 and 0023852X
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- The Laryngoscope
- Accession number :
- edsair.doi.dedup.....2e092e81f354dc50b5c88b3c1c313c13