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Reactivation of BK virus after double umbilical cord blood transplantation in adults correlates with impaired reconstitution of CD4+ and CD8+ T effector memory cells and increase of T regulatory cells
- Source :
- Clin Immunol
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- BK virus (BKV), a human polyomavirus that remains latent in renal epithelial cells, can be reactivated after hematopoietic stem cell transplantation (HSCT) leading to hemorrhagic cystitis. The incidence of BK viremia is higher after Umbilical cord blood transplantation (UCBT) than HSCT from adult donors. Data regarding the role of immune recovery after UCBT in BKV reactivation is lacking. We examined the correlation between the development of BK viremia and immune reconstitution in 27 adult recipients of UCBT. The incidence of BK viremia was 52% and developed most frequently within the first 8 weeks after the transplantation, but persisted in seven patients at 6 months, and three patients at 1-year post UCBT. Detection of BK viremia 1 year after transplant was negatively associated with the number of CD8+ cells (p = 0.03) and CD8+CD45RO+ cells (p = 0.05) at 6 months, and the number of CD4+ (p = 0.03) and CD4+CD45RO+ cells (p = 0.03) at 12 months after UCBT. Conversely, BK viremia at 6 and 12 months was positively correlated with the number of T regulatory (Treg) cells at 1 month (p = 0.005 and p = 0.016, respectively). Because UCB Treg have highly potent immunosuppressive function, our findings indicate that sustained BK viremia in UCBT recipients might be associated with the increase of Treg cells early after transplantation, which mediate impaired and delayed reconstitution of CD4+ and CD8+ T effector cells.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_treatment
Immunology
Viremia
Hematopoietic stem cell transplantation
Antibodies, Viral
medicine.disease_cause
Article
Young Adult
03 medical and health sciences
0302 clinical medicine
Immune system
T-Lymphocyte Subsets
Humans
Immunology and Allergy
Medicine
Aged
Polyomavirus Infections
business.industry
Umbilical Cord Blood Transplantation
Middle Aged
medicine.disease
BK virus
Transplantation
Tumor Virus Infections
030104 developmental biology
BK Virus
Cord blood
DNA, Viral
Female
Virus Activation
Cord Blood Stem Cell Transplantation
business
CD8
030215 immunology
Subjects
Details
- ISSN :
- 15216616
- Volume :
- 207
- Database :
- OpenAIRE
- Journal :
- Clinical Immunology
- Accession number :
- edsair.doi.dedup.....2df6849e3e91647708f45bae93763d25