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Metabolic syndrome severity is significantly associated with future coronary heart disease in Type 2 diabetes
- Source :
- Cardiovascular Diabetology, Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-9 (2018)
- Publication Year :
- 2018
- Publisher :
- BioMed Central, 2018.
-
Abstract
- Background The severity of the metabolic syndrome (MetS) is significantly associated with future coronary heart disease (CHD) among individuals without baseline Type 2 diabetes. However, the validity of assessing MetS severity among individuals with diabetes is unknown. Objective To assess for differences in MetS severity by timing of Type 2 diabetes diagnosis and to assess for associations between MetS severity and future CHD among individuals with diabetes. Methods We analyzed data from participants of the Atherosclerosis Risk in Communities study, including 1419 with- and 7241 without diabetes, followed during 4 visits and adjudicated CHD diagnoses over a 20-year period. We used Cox-regression techniques to assess hazard ratios (HR) of CHD based on a sex- and race/ethnicity-specific MetS-severity Z-score (standard MetS score) and a similar MetS-severity score formulated without incorporating glucose as a component of MetS (no-glucose MetS score). Results For both the standard- and no-glucose MetS-severity scores, scores were highest in the baseline-diabetes group, lowest in the never-diabetes group and intermediate in the incident-diabetes groups. Among participants with diabetes, increasing MetS-severity score at baseline was associated with incident CHD, using both the standard MetS score (HR 1.29, 95% confidence interval [CI] 1.21, 1.39) and the no-glucose score (HR 1.42, CI 1.24, 1.62) (both p
- Subjects :
- Risk
Blood Glucose
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Blood Pressure
Coronary Disease
Type 2 diabetes
030204 cardiovascular system & hematology
Risk Assessment
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Risk Factors
Diabetes mellitus
Internal medicine
medicine
Humans
Angiology
Original Investigation
Glycated Hemoglobin
Metabolic Syndrome
business.industry
Hazard ratio
Diabetes
Middle Aged
medicine.disease
Cardiovascular disease
Prognosis
Lipids
Coronary heart disease
Confidence interval
United States
3. Good health
Atherosclerosis Risk in Communities
Diabetes Mellitus, Type 2
lcsh:RC666-701
Disease Progression
Female
Metabolic syndrome
Waist Circumference
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 14752840
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Diabetology
- Accession number :
- edsair.doi.dedup.....2de553721f9b6f177b92d6ac0914b633