Back to Search
Start Over
Is There Any Relationship between Metabolic Parameters and Left Ventricular Functions in Type 2 Diabetic Patients without Evident Heart Disease?
- Source :
- Echocardiography. 25:675-682
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- BACKGROUND The aim of the present study was to evaluate left ventricle (LV) systolic and diastolic function, using tissue Doppler echocardiography (TDE) and color M-mode flow propagation velocity, in relation to blood glucose status in normotensive patients with type 2 diabetes mellitus (T2DM) who had no clinical evidence of heart disease. METHODS Seventy-two patients with T2DM (mean age 49.1 +/- 9.8 years) without symptoms, signs or history of heart disease and hypertension, and 50 ages matched healthy controls (mean age 46.1 +/- 9.8 years) had echocardiography. Systolic and diastolic LV functions were detected by using conventional echocardiography, TDE and mitral color M-mode flow propagation velocity (V(E)). Fasting blood glucose level (FBG) after 8 hours since eating a meal, postprandial blood glucose level (PPG), and HbA(1C) level were determined. The association of FBG, PPG and HbA(1C) with the echocardiographic parameters was investigated. RESULTS It was detected that although systolic functions of two groups were similar, diastolic functions were significantly impaired in diabetics. No relation of FBG and PPG with systolic and diastolic functions was determined. However, HbA(1C) was found to be related to diastolic parameters such as E/A, Em/Am, V(E) and E/V(E) (beta=-0.314, P = < 0.05; beta=-0.230, P < 0.05; beta=-0.602, P < 0.001, beta= 0.387, P < 0.005, respectively). In addition to HbA(1C), LV, diastolic functions were also correlated with age and diabetes duration. CONCLUSION Diastolic LV dysfunction may develop even in absence of ischemia, hypertension, and LVH in T2DM. FBG and PPG have no effect on LV functions, but HbA(1C) levels may affect diastolic parameters.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Heart Diseases
Heart disease
Ventricular Dysfunction, Right
Diastole
Sensitivity and Specificity
Severity of Illness Index
Ventricular Dysfunction, Left
Tissue Doppler echocardiography
Heart Rate
Reference Values
Diabetes mellitus
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Probability
Echocardiography, Doppler, Pulsed
E/A ratio
business.industry
Blood Pressure Determination
Stroke Volume
Stroke volume
Middle Aged
medicine.disease
Echocardiography, Doppler, Color
medicine.anatomical_structure
Postprandial
Diabetes Mellitus, Type 2
Ventricle
Case-Control Studies
Multivariate Analysis
Cardiology
Regression Analysis
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15408175 and 07422822
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Echocardiography
- Accession number :
- edsair.doi.dedup.....2de47cde5ac15301ee8a87e4459d5c9f