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Sign and magnitude scaling properties of heart rate variability in patients with end-stage renal failure: Are these properties useful to identify pathophysiological adaptations?
- Source :
- Chaos (Woodbury, N.Y.). 27(9)
- Publication Year :
- 2017
-
Abstract
- The scaling properties of heart rate variability data are reliable dynamical features to predict mortality and for the assessment of cardiovascular risk. The aim of this manuscript was to determine if the scaling properties, as provided by the sign and magnitude analysis, can be used to differentiate between pathological changes and those adaptations basically introduced by modifications of the mean heart rate in distinct manoeuvres (active standing or hemodialysis treatment, HD), as well as clinical conditions (end stage renal disease, ESRD). We found that in response to active standing, the short-term scaling index (α1) increased in healthy subjects and in ESRD patients only after HD. The sign short-term scaling exponent (α1sign) increased in healthy subjects and ESRD patients, showing a less anticorrelated behavior in active standing. Both α1 and α1sign did show covariance with the mean heart rate in healthy subjects, while in ESRD patients, this covariance was observed only after HD. A reliable estimation of the magnitude short-term scaling exponent (α1magn) required the analysis of time series with a large number of samples (>3000 data points). This exponent was similar for both groups and conditions and did not show covariance with the mean heart rate. A surrogate analysis confirmed the presence of multifractal properties (α1magn > 0.5) in the time series of healthy subjects and ESDR patients. In conclusion, α1 and α1sign provided insights into the physiological adaptations during active standing, which revealed a transitory impairment before HD in ESRD patients. The presence of multifractal properties indicated that a reduced short-term variability does not necessarily imply a declined regulatory complexity in these patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
General Physics and Astronomy
Hemodynamics
030204 cardiovascular system & hematology
01 natural sciences
End stage renal disease
03 medical and health sciences
0302 clinical medicine
Heart Rate
Internal medicine
0103 physical sciences
Heart rate
medicine
Heart rate variability
Humans
010306 general physics
Pathological
Mathematical Physics
business.industry
Applied Mathematics
Statistical and Nonlinear Physics
Regression analysis
Covariance
Cardiology
Kidney Failure, Chronic
Regression Analysis
Female
Hemodialysis
business
Subjects
Details
- ISSN :
- 10897682
- Volume :
- 27
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Chaos (Woodbury, N.Y.)
- Accession number :
- edsair.doi.dedup.....2de029ac7f50c14d4cddcf6a8880ef6a