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Predictability of Macrosomic Birth based on Maternal Factors and Fetal Aneuploidy Screening Biochemical Markers in Hyperglycemic Mothers
- Source :
- International Journal of Medical Sciences
- Publication Year :
- 2021
- Publisher :
- Ivyspring International Publisher, 2021.
-
Abstract
- Background: Macrosomic birth weight has been implicated as a significant risk factor for developing various adult metabolic diseases such as diabetes mellitus and coronary heart diseases; it has also been associated with higher incidences of complicated births. This study aimed to examine the predictability of macrosomic births in hyperglycemic pregnant women using maternal clinical characteristics and serum biomarkers of aneuploidy screening performed in the first half of pregnancy. Methods: A retrospective observational study was performed on a cohort of 1,668 pregnant women who 1) had positive outcomes after undergoing 50-g oral glucose challenge test (OGCT) at two university-based hospitals and 2) underwent any one of the following maternal biomarker screening tests for fetal aneuploidy: triple test, quadruple test, and integrated test. Logistic regression-based models for predicting macrosomic births using maternal characteristics and serum biomarkers were developed and evaluated for prediction power. A nomogram, which is a graphical display of the best predictable model, was then generated. Results: The study cohort included 157 macrosomic birth cases defined as birth weight ≥3,820 g, which was equivalent to the top 10 percentile of the modeling cohort. Three primary models solely based on serum biomarkers achieved area under curves (AUCs) of 0.55-0.62. Expanded models, including maternal demographic and clinical factors, demonstrated an improved performance by 25% (AUCs, 0.69-0.73). Conclusion: Our prediction models will help to identify pregnancies with an elevated risk of macrosomic births in hyperglycemic mothers using maternal clinical factors and serum markers from routine antenatal screening tests. Prediction of macrosomic birth at mid-pregnancy may allow customized antenatal care to reduce the risk of macrosomic births.
- Subjects :
- Adult
Blood Glucose
medicine.medical_specialty
maternal biomarker
Birth weight
Logistic regression
Fetal Macrosomia
nomogram
03 medical and health sciences
0302 clinical medicine
Pregnancy
Risk Factors
Diabetes mellitus
medicine
Birth Weight
Humans
macrosomic births
Retrospective Studies
medicine.diagnostic_test
Obstetrics
business.industry
Triple test
maternal hyperglycemia
Infant, Newborn
Retrospective cohort study
General Medicine
Glucose Tolerance Test
Nomogram
Aneuploidy
medicine.disease
Diabetes, Gestational
Hyperglycemia
Cohort
Female
030211 gastroenterology & hepatology
business
Biomarkers
Maternal Serum Screening Tests
Maternal Age
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 14491907
- Volume :
- 18
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- International Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....2dd1e11c8ded2ea6e7002a1020a47f44