Back to Search
Start Over
euHCVdb: the European hepatitis C virus database
- Source :
- Nucleic Acids Research, Nucleic Acids Research, Oxford University Press, 2007, 35 (Database issue), pp.D363-6. ⟨10.1093/nar/gkl970⟩
- Publication Year :
- 2007
- Publisher :
- Oxford University Press (OUP), 2007.
-
Abstract
- International audience; The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, http://euhcvdb.ibcp.fr), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses.
- Subjects :
- MESH: Databases, Protein
Models, Molecular
MESH: Sequence Analysis, Protein
Protein Conformation
Hepatitis C virus
Genome, Viral
Hepacivirus
Viral quasispecies
Biology
computer.software_genre
medicine.disease_cause
Genome
User-Computer Interface
Viral Proteins
03 medical and health sciences
MESH: Protein Conformation
Gene mapping
Sequence Analysis, Protein
Genetics
medicine
MESH: Hepacivirus
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Databases, Protein
MESH: User-Computer Interface
030304 developmental biology
Sequence (medicine)
Internet
0303 health sciences
Database
030306 microbiology
MESH: Genomics
Genomics
Articles
Hepatitis C
medicine.disease
MESH: Viral Proteins
Subtyping
3. Good health
MESH: Internet
Molecular virology
MESH: Genome, Viral
computer
MESH: Models, Molecular
Subjects
Details
- ISSN :
- 13624962 and 03051048
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Nucleic Acids Research
- Accession number :
- edsair.doi.dedup.....2dce76ef1800b53b4c10269217a17f2f