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Phenotypic and lifestyle determinants of HbA1c in the general population-The Hoorn Study
- Source :
- PLoS ONE, Vol 15, Iss 6, p e0233769 (2020), PLoS ONE, PLoS ONE 15 (2020) 6, PLoS ONE, 15(6):e0233769. Public Library of Science, PLoS ONE, 15(6), Wisgerhof, W, Ruijgrok, C, den Braver, N R, Borgonjen-van den Berg, K J, van der Heijden, A A W A, Elders, P J M, Beulens, J W J & Alssema, M 2020, ' Phenotypic and lifestyle determinants of HbA1c in the general population-The Hoorn Study ', PLoS ONE, vol. 15, no. 6, e0233769, pp. e0233769 . https://doi.org/10.1371/journal.pone.0233769
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- AIM: To investigate the relative contribution of phenotypic and lifestyle factors to HbA1c, independent of fasting plasma glucose (FPG) and 2h post-load glucose (2hPG), in the general population. METHODS: The study populations included 2309 participants without known diabetes from the first wave of the Hoorn Study (1989) and 2619 from the second wave (2006). Multivariate linear regression models were used to analyze the relationship between potential determinants and HbA1c in addition to FPG and 2hPG. The multivariate model was derived in the first wave of the Hoorn Study, and replicated in the second wave. RESULTS: In both cohorts, independent of FPG and 2hPG, higher age, female sex, larger waist circumference, and smoking were associated with a higher HbA1c level. Larger hip circumference, higher BMI, higher alcohol consumption and vitamin C intake were associated with a lower HbA1c level. FPG and 2hPG together explained 41.0% (first wave) and 53.0% (second wave) of the total variance in HbA1c. The combination of phenotypic and lifestyle determinants additionally explained 5.7% (first wave) and 3.9% (second wave). CONCLUSIONS: This study suggests that, independent of glucose, phenotypic and lifestyle factors are associated with HbA1c, but the contribution is relatively small. These findings contribute to a better understanding of the low correlation between glucose levels and HbA1c in the general population.
- Subjects :
- Blood Glucose
Male
Multivariate statistics
endocrine system diseases
Ascorbic Acid
Biochemistry
Body Mass Index
Cohort Studies
0302 clinical medicine
Endocrinology
Mathematical and Statistical Techniques
Bayesian multivariate linear regression
Diabetes diagnosis and management
Medicine
030212 general & internal medicine
Vitamin C
education.field_of_study
Multidisciplinary
Alcohol Consumption
Organic Compounds
Monosaccharides
Statistics
Smoking
Age Factors
Vitamins
Fasting
Middle Aged
Circumference
Chemistry
Phenotype
Creatinine
Physical Sciences
Regression Analysis
Female
Waist Circumference
Cohort study
Research Article
Waist
HbA1c
Alcohol Drinking
Endocrine Disorders
Science
Population
Carbohydrates
030209 endocrinology & metabolism
OS&DAEB
Linear Regression Analysis
Research and Analysis Methods
03 medical and health sciences
Sex Factors
Diabetes mellitus
Diabetes Mellitus
Life Science
Humans
Hemoglobin
Statistical Methods
education
Life Style
Nutrition
Aged
Global Nutrition
Medicine and health sciences
Glycated Hemoglobin
Wereldvoeding
Biology and life sciences
business.industry
Organic Chemistry
Chemical Compounds
Proteins
nutritional and metabolic diseases
Glucose Tolerance Test
medicine.disease
Diagnostic medicine
Diet
Glucose
Diabetes Mellitus, Type 2
Metabolic Disorders
business
Body mass index
Biomarkers
Mathematics
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....2dc21f9c6ad0dcda0cb2b060040ed0b8