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Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes

Authors :
Odile Oxybel
Yannick Brouste
Jonathan Florentin
Hossein Mehdaoui
Papa Gueye
Dabor Resiere
Cyrille Chabartier
Bruno Mégarbane
Hatem Kallel
Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique]
Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
Agence régionale de santé (ARS) de Martinique (ARS Martinique)
Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144))
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
Mégarbane, Bruno
Source :
Toxics, Volume 8, Issue 2, Toxics, Vol 8, Iss 28, p 28 (2020), Toxics, 2020, 8 (2), pp.28. ⟨10.3390/toxics8020028⟩
Publication Year :
2020
Publisher :
Multidisciplinary Digital Publishing Institute, 2020.

Abstract

The epidemiology of severe acute poisonings in the French overseas departments of the Americas remains poorly reported. The main objective of this study was to determine the epidemiology and characteristics of severe acutely poisoned adult patients. Methods: A retrospective descriptive study was conducted from 1 January 2000 to 31 December 2010 in severely poisoned patients presenting to the emergency department (ED) of the University Hospital of Martinique, and the general public hospitals of Lamentin and Trinit&eacute<br />Results: During the study period, 291 patients were admitted for severe poisoning, giving an incidence rate of 7.7 severe cases/100,000 inhabitants. The mean age was 46 &plusmn<br />19 years and 166 (57%) were male. Psychiatric disorders were recorded in 143 (49.8%) patients. Simplified Acute Psychological Score (SAPS II) at admission was 39 &plusmn<br />23 points and Poisoning Severity Score (PSS) was 2.7 &plusmn<br />0.8 points. Death was recorded in 30 (10.3%) patients and hospital length of stay was 6 &plusmn<br />7 days. The mode of intoxication was intentional self-poisoning in 87% of cases and drug overdose was recorded in 13% of cases. The toxic agent involved was a therapeutic drug in 58% and a chemical product in 52% of cases. The predominant clinical manifestations were respiratory failure (59%), hemodynamic failure (27%), neurologic failure (45%), gastrointestinal manifestations (27%), and renal failure (11%). Polypnea, shock, ventricular fibrillation or tachycardia, and gastro-intestinal disorders were the main symptoms associated with death. The main biological abnormalities associated with death in our patients were metabolic acidosis, hypokalemia, hyperlactatemia, hypocalcemia, renal injury, rhabdomyolysis, increased aspartate aminotransferases, and thrombocytopenia. Extracorporal membrane oxygenation (ECMO) was used in three patients and specific antidotes were used in 21% of patients. Conclusions: Acute poisonings remain a major public health problem in Martinique with different epidemiological characteristics to those in mainland France, with a high incidence of poisoning by rural and household toxins.

Details

Language :
English
ISSN :
23056304
Database :
OpenAIRE
Journal :
Toxics
Accession number :
edsair.doi.dedup.....2db2dad4d57937f2bf9c13ef352f791d
Full Text :
https://doi.org/10.3390/toxics8020028