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A Cartilage Growth Mixture Model With Collagen Remodeling: Validation Protocols
- Source :
- Journal of Biomechanical Engineering. 130
- Publication Year :
- 2008
- Publisher :
- ASME International, 2008.
-
Abstract
- A cartilage growth mixture (CGM) model is proposed to address limitations of a model used in a previous study. New stress constitutive equations for the solid matrix are derived and collagen (COL) remodeling is incorporated into the CGM model by allowing the intrinsic COL material constants to evolve during growth. An analytical validation protocol based on experimental data from a recent in vitro growth study is developed. Available data included measurements of tissue volume, biochemical composition, and tensile modulus for bovine calf articular cartilage (AC) explants harvested at three depths and incubated for 13days in 20% fetal borine serum (FBS) and 20% FBS+β-aminopropionitrile. The proposed CGM model can match tissue biochemical content and volume exactly while predicting theoretical values of tensile moduli that do not significantly differ from experimental values. Also, theoretical values of a scalar COL remodeling factor are positively correlated with COL cross-link content, and mass growth functions are positively correlated with cell density. The results suggest that the CGM model may help us to guide in vitro growth protocols for AC tissue via the a priori prediction of geometric and biomechanical properties.
- Subjects :
- Cartilage, Articular
endocrine system diseases
Computer science
Biomedical Engineering
Swelling pressure
Cell Count
Articular cartilage
Young's modulus
macromolecular substances
Matrix (biology)
Models, Biological
Sensitivity and Specificity
Article
Model validation
Tissue Culture Techniques
Extracellular matrix
symbols.namesake
Tissue engineering
Physiology (medical)
Ultimate tensile strength
medicine
Animals
Tissue Engineering
Cartilage
Reproducibility of Results
Mixture model
Biomechanical Phenomena
Extracellular Matrix
Structure and function
medicine.anatomical_structure
Fixed charge
symbols
Cattle
Collagen
In vitro growth
Mathematics
Biomedical engineering
Explant culture
Subjects
Details
- ISSN :
- 15288951 and 01480731
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Journal of Biomechanical Engineering
- Accession number :
- edsair.doi.dedup.....2dad18a1a954449852dd41ffd1664ca2