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Chitosan impregnation with biologically active tryaryl imidazoles in supercritical carbon dioxide
- Source :
- Journal of materials science. Materials in medicine. 27(9)
- Publication Year :
- 2016
-
Abstract
- The presented paper is focused on impregnation of chitosan and its derivatives with a biologically active triaryl imidazole model compound ((2-2-hydroxyphenyl)-4.5-diphenyl-1H-imidazole) in the supercritical carbon dioxide medium. Since initial chitosan represents a polycation-exchange resin and does not swell in supercritical carbon dioxide, the impregnation was carried out in the presence of water (0.15-3.0 vol%). The maximum 2-2-hydroxyphenyl)-4.5-diphenyl-1H-imidazole concentration in a chitosan film was achieved at the ~5 × 10(-3) g/cm(3) water content in the reactor. We also used hydroxy carboxylic acid derivatives of chitosan and its copolymer with polylactide as matrices for introduction of hydrophobic 2-2-hydroxyphenyl)-4.5-diphenyl-1H-imidazole. We have shown that unmodified chitosan contains the greatest amount of 2-2-hydroxyphenyl)-4.5-diphenyl-1H-imidazole, as compared with its hydrophobic derivatives. The kinetics of 2-2-hydroxyphenyl)-4.5-diphenyl-1H-imidazole diffusion from a chitosan matrix was studied in acidified water with pH 1.6. We found that the complete release of 2-2-hydroxyphenyl)-4.5-diphenyl-1H-imidazole into the aqueous phase from unmodified chitosan films occurred in 48 h, while its complete release from chitosan modified with hydroxy carboxylic acids occurred in 5 min or less.
- Subjects :
- Materials science
Luminescence
Polymers
Diffusion
Carboxylic acid
Kinetics
Biomedical Engineering
Biophysics
Carboxylic Acids
Bioengineering
Biocompatible Materials
02 engineering and technology
010402 general chemistry
01 natural sciences
Biomaterials
Chitosan
chemistry.chemical_compound
Drug Delivery Systems
Cations
Copolymer
Pressure
Organic chemistry
Imidazole
chemistry.chemical_classification
Supercritical carbon dioxide
Aqueous two-phase system
Imidazoles
Temperature
Water
Green Chemistry Technology
Carbon Dioxide
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
0104 chemical sciences
chemistry
Solvents
Spectrophotometry, Ultraviolet
0210 nano-technology
Subjects
Details
- ISSN :
- 15734838
- Volume :
- 27
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of materials science. Materials in medicine
- Accession number :
- edsair.doi.dedup.....2dacbf95ef45f2e5d71c0eb5dd8e96a9