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The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4
- Source :
- Chemical Communications (Cambridge, England), Cai, Xingguang; Javor, Sacha; Gan, Bee Ha; Köhler, Thilo; Reymond, Jean-Louis (2021). The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4. Chemical communications, 57(46), pp. 5654-5657. Royal Society of Chemistry 10.1039/D1CC01838H
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry, 2021.
-
Abstract
- pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.<br />A previously unknown pH-effect on the antimicrobial activity of peptide dendrimers and polymyxin B against Klebsiella pneumoniae and MRSA is reported.
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
Dendrimers
Klebsiella pneumoniae
Molecular Conformation
Peptide
Microbial Sensitivity Tests
Molecular Dynamics Simulation
010402 general chemistry
medicine.disease_cause
01 natural sciences
Catalysis
Microbiology
Dendrimer
540 Chemistry
Materials Chemistry
medicine
Polymyxin B
chemistry.chemical_classification
biology
010405 organic chemistry
Metals and Alloys
General Chemistry
Hydrogen-Ion Concentration
Antimicrobial
biology.organism_classification
3. Good health
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Anti-Bacterial Agents
Chemistry
chemistry
Staphylococcus aureus
Ceramics and Composites
570 Life sciences
Antibacterial activity
Peptides
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Chemical Communications (Cambridge, England), Cai, Xingguang; Javor, Sacha; Gan, Bee Ha; Köhler, Thilo; Reymond, Jean-Louis (2021). The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4. Chemical communications, 57(46), pp. 5654-5657. Royal Society of Chemistry 10.1039/D1CC01838H <http://dx.doi.org/10.1039/D1CC01838H>
- Accession number :
- edsair.doi.dedup.....2da42a6bb2414d9b58100b917406bec0
- Full Text :
- https://doi.org/10.48350/163002