Back to Search
Start Over
Evaluation of the acute and sub-acute toxicity of the black caraway seed essential oil in Wistar rats
- Source :
- Toxicology Reports, Toxicology Reports, Vol 6, Iss, Pp 869-874 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Graphical abstract Haematological (right) and biochemical (left) parameter.<br />Highlights • The black caraway essential oil was considered as practically low-toxic. • Sub-acute study the results demonstrate histological damages and no biochemical and hematological changes. • The black caraway essential oil exhibited no acute toxicity. • The black caraway essential oil as an alternative to synthetic drug can be used.<br />The aim of the present study was to evaluate the acute toxicity as lethal dose 50% (LD50) and sub-acute toxicity of the black caraway Bunium persicum (Bioss) seed essential oil in male Wistar rats. The compounds of B. persicum were identified by GC/MS and amount of each compound was evaluated. 21 different compounds were determined in the essential oil and the main components were: carvone, p-cymene, gamma-terpinene, p-cymene-8-ol, limonene, isoterpinolene, and 2-beta pinene. For acute toxicity evaluation, the animals were randomly divided into nine group (n = 6) and received 500, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg seed essential oil, respectively and the LD50 value for black caraway seed essential oil was obtained above 4000 mg/kg body weight. According to data, treatment with the black caraway seed essential oil sub-acute toxicity study attenuated histopathological changes in lung, liver, kidney, testes and spleen tissues and the results of this study show that the black caraway essential oil can not affect the immune and blood system, important enzymes and vital organs of the body..
- Subjects :
- food.ingredient
Health, Toxicology and Mutagenesis
010501 environmental sciences
Biology
Toxicology
01 natural sciences
Median lethal dose
Article
Essential oil
law.invention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
food
lcsh:RA1190-1270
law
lcsh:Toxicology. Poisons
0105 earth and related environmental sciences
Bunium persicum
Limonene
Pinene
Carvone
Acute toxicity
Black caraway (Bunium persicum)
Traditional medicine
Sub-acute toxicity
chemistry
Toxicity
Rat
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22147500
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Toxicology Reports
- Accession number :
- edsair.doi.dedup.....2d90cef12fdf53753c0d859210c54603