Back to Search
Start Over
Development and Validation of an Early Mortality Risk Score for Older Patients Treated with Chemotherapy for Cancer
- Source :
- Journal of Clinical Medicine, r-FISABIO. Repositorio Institucional de Producción Científica, instname, Dipòsit Digital de la UB, Universidad de Barcelona, Journal of clinical medicine, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Journal of Clinical Medicine, Vol 10, Iss 1615, p 1615 (2021), Volume 10, Issue 8, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Biblos-e Archivo. Repositorio Institucional de la UAM
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Background: Estimation of life expectancy in older patients is relevant to select the best treatment strategy. We aimed to develop and validate a score to predict early mortality in older patients with cancer. Patients and Methods: A total of 749 patients over 70 years starting new chemotherapy regimens were prospectively included. A prechemotherapy assessment that included sociodemographic variables, tumor/treatment variables, and geriatric assessment variables was performed. Association between these factors and early death was examined using multivariable logistic regression. Score points were assigned to each risk factor. External validation was performed on an independent cohort. Results: In the training cohort, the independent predictors of 6-month mortality were metastatic stage (OR 4.8, 95% CI [2.4–9.6]), ECOG-PS 2 (OR 2.3, 95% CI [1.1–5.2]), ADL≤5 (OR 1.7, 95% CI [1.1–3.5]), serum albumin levels ≤ 3.5 g/dL (OR 3.4, 95% CI [1.7–6.6]), BMI &lt<br />23 kg/m2 (OR 2.5, 95% CI [1.3–4.9]), and hemoglobin levels &lt<br />11 g/dL (OR 2.4, 95% CI (1.2–4.7)). With these results, we built a prognostic score. The area under the ROC curve was 0.78 (95% CI, 0.73 to 0.84), and in the validation set, it was 0.73 (95% CI: 0.67–0.79). Conclusions: This simple and highly accurate tool can help physicians making decisions in elderly patients with cancer who are planned to initiate chemotherapy treatment.
- Subjects :
- medicine.medical_specialty
Medicina
geriatric assessment
medicine.medical_treatment
Anciano
lcsh:Medicine
Antineoplastic Agents
030204 cardiovascular system & hematology
risk score
Logistic regression
chemotherapy
Article
03 medical and health sciences
0302 clinical medicine
older patient
Risk Factors
early death
Internal medicine
Quimioteràpia
medicine
Mortalitat
Stage (cooking)
Risk factor
Mortality
Càncer
Aged
Cancer
Factores de Riesgo
Chemotherapy
Framingham Risk Score
business.industry
lcsh:R
General Medicine
medicine.disease
Antineoplásicos
030220 oncology & carcinogenesis
Cohort
Mortalidad
Life expectancy
business
prognostic
Subjects
Details
- ISSN :
- 20770383
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine, r-FISABIO. Repositorio Institucional de Producción Científica, instname, Dipòsit Digital de la UB, Universidad de Barcelona, Journal of clinical medicine, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Journal of Clinical Medicine, Vol 10, Iss 1615, p 1615 (2021), Volume 10, Issue 8, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Biblos-e Archivo. Repositorio Institucional de la UAM
- Accession number :
- edsair.doi.dedup.....2d8c6f30d6943286d7b6126145ff2094