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Molecular and cellular intratumoral heterogeneity in primary glioblastoma: clinical and translational implications
- Source :
- Journal of Neurosurgery. 133:655-663
- Publication Year :
- 2020
- Publisher :
- Journal of Neurosurgery Publishing Group (JNSPG), 2020.
-
Abstract
- Glioblastoma (GBM), the most common primary malignant brain tumor in adults, is associated with significant morbidity and mortality despite maximal safe resection followed by chemo- and radiotherapy. GBMs contain self-renewing, tumorigenic glioma stem cells that contribute to tumor initiation, heterogeneity, therapeutic resistance, and recurrence. Intratumoral heterogeneity (ITH) of GBMs is also a major contributing factor to poor clinical outcomes associated with these high-grade glial tumors. Herein, the authors summarize recent discoveries and advances in the molecular and phenotypic characterization of GBMs with particular focus on ITH. In so doing, they attempt to highlight recent advances in molecular signatures/properties and metabolic alterations in an effort to clarify translational implications that may ultimately improve clinical outcomes.
- Subjects :
- Primary Glioblastoma
0303 health sciences
business.industry
medicine.medical_treatment
General Medicine
Tumor initiation
Therapeutic resistance
medicine.disease
Phenotype
nervous system diseases
Radiation therapy
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
Glioma
Cancer research
Medicine
Stem cell
business
neoplasms
030304 developmental biology
Glioblastoma
Subjects
Details
- ISSN :
- 19330693 and 00223085
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Journal of Neurosurgery
- Accession number :
- edsair.doi.dedup.....2d8af2b3e26604d76bbb1390e2041ae3