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Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes
- Source :
- Nutrients, Nutrients, Vol 6, Iss 12, Pp 5724-5739 (2014)
- Publication Year :
- 2014
- Publisher :
- MDPI, 2014.
-
Abstract
- We can now sequence and identify genome wide epigenetic patterns and perform a variety of “genomic experiments” within relatively short periods of time—ranging from days to weeks. Yet, despite these technological advances, we have a poor understanding of the inter-relationships between epigenetics, genome structure-function, and nutrition. Perhaps this limitation lies, in part, in our propensity to study epigenetics in terms of the linear arrangement of elements and genes. Here we propose that a more complete understanding of how nutrition impacts on epigenetics and cellular development resides within the inter-relationships between DNA and histone modification patterns and genome function, in the context of spatial organization of chromatin and the epigenome.
- Subjects :
- Epigenomics
Context (language use)
lcsh:TX341-641
Review
Biology
Genome
Epigenesis, Genetic
Histones
Nutrigenomics
estrogen
Animals
Humans
genome organization
Epigenetics
Genomic organization
Genetics
Nutrition and Dietetics
epigenetics
Estrogens
Epigenome
DNA Methylation
CTCF
Chromatin
Diet
cohesion
nutrition
Evolutionary biology
proximity ligation
lcsh:Nutrition. Foods and food supply
HiC
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 6
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....2d898d36c1a87f9a7e96bc37ecd3f995