Back to Search
Start Over
Report on influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza in 2018
- Source :
- Communicable diseases intelligence (2018). 44
- Publication Year :
- 2020
-
Abstract
- As part of its role in the World Health Organization’s (WHO) Global Influenza Surveillance and Response System (GISRS), the WHO Collaborating Centre for Reference and Research on Influenza in Melbourne received a total of 3993 human influenza-positive samples during 2018. Viruses were analysed for their antigenic, genetic and antiviral susceptibility properties. Selected viruses were propagated in qualified cells or hens’ eggs for use as potential seasonal influenza vaccine virus candidates. In 2018, influenza A(H1)pdm09 viruses predominated over influenza A(H3) and B viruses, accounting for a total of 53% of all viruses analysed. The majority of A(H1)pdm09, A(H3) and influenza B viruses analysed at the Centre were found to be antigenically similar to the respective WHO-recommended vaccine strains for the Southern Hemisphere in 2018. However, phylogenetic analysis indicated that a significant proportion of circulating A(H3) viruses had undergone genetic drift relative to the WHO-recommended vaccine strain for 2018. Of 2864 samples tested for susceptibility to the neuraminidase inhibitors oseltamivir and zanamivir, three A(H1)pdm09 viruses showed highly reduced inhibition by oseltamivir, while one B/Victoria virus showed highly reduced inhibition by both oseltamivir and zanamivir.
- Subjects :
- 0301 basic medicine
Oseltamivir
medicine.medical_specialty
viruses
030106 microbiology
Drug resistance
medicine.disease_cause
World Health Organization
Antiviral Agents
Virus
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Zanamivir
Antigen
Molecular genetics
Drug Resistance, Viral
Influenza, Human
Influenza A virus
medicine
Animals
Humans
030212 general & internal medicine
Antigens, Viral
Phylogeny
biology
Australia
virus diseases
General Medicine
Virology
Influenza B virus
chemistry
Influenza Vaccines
biology.protein
Neuraminidase
Chickens
medicine.drug
Subjects
Details
- ISSN :
- 22096051
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Communicable diseases intelligence (2018)
- Accession number :
- edsair.doi.dedup.....2d6e5a3d7598cd3486e41ae2ef2e2b20