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Computational modeling of human bone fracture healing affected by different conditions of initial healing stage
- Source :
- BMC Musculoskeletal Disorders, BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-14 (2019)
- Publication Year :
- 2019
- Publisher :
- BioMed Central, 2019.
-
Abstract
- Background Bone healing process includes four phases: inflammatory response, soft callus formation, hard callus development, and remodeling. Mechanobiological models have been used to investigate the role of various mechanical and biological factors on bone healing. However, the effects of initial healing phase, which includes the inflammatory stage, the granulation tissue formation, and the initial callus formation during the first few days post-fracture, are generally neglected in such studies. Methods In this study, we developed a finite-element-based model to simulate different levels of diffusion coefficient for mesenchymal stem cell (MSC) migration, Young’s modulus of granulation tissue, callus thickness and interfragmentary gap size to understand the modulatory effects of these initial phase parameters on bone healing. Results The results quantified how faster MSC migration, stiffer granulation tissue, thicker callus, and smaller interfragmentary gap enhanced healing to some extent. However, after a certain threshold, a state of saturation was reached for MSC migration rate, granulation tissue stiffness, and callus thickness. Therefore, a parametric study was performed to verify that the callus formed at the initial phase, in agreement with experimental observations, has an ideal range of geometry and material properties to have the most efficient healing time. Conclusions Findings from this paper quantified the effects of the initial healing phase on healing outcome to better understand the biological and mechanobiological mechanisms and their utilization in the design and optimization of treatment strategies. It is also demonstrated through a simulation that for fractures, where bone segments are in close proximity, callus development is not required. This finding is consistent with the concepts of primary and secondary bone healing.
- Subjects :
- Mechanobiological modeling
lcsh:Diseases of the musculoskeletal system
Callus formation
0206 medical engineering
Finite Element Analysis
Healing time
Human bone
02 engineering and technology
Bone healing
03 medical and health sciences
Fractures, Bone
Migration rate
Rheumatology
Elastic Modulus
Medicine
Animals
Humans
Orthopedics and Sports Medicine
Computer Simulation
Bone fracture healing
030304 developmental biology
Fracture Healing
0303 health sciences
business.industry
Inflammatory stage
Mesenchymal stem cell
Granulation tissue
Granulation tissue material properties
musculoskeletal system
020601 biomedical engineering
Biomechanical Phenomena
medicine.anatomical_structure
Initial phase
Callus
lcsh:RC925-935
business
Initial callus size
Biomedical engineering
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712474
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Musculoskeletal Disorders
- Accession number :
- edsair.doi.dedup.....2d6d05c1b8f19ca308bb24cd4aaf7f2f