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Association of schistosomiasis and HIV infections: A systematic review and meta-analysis
- Source :
- International Journal of Infectious Diseases, Vol 102, Iss, Pp 544-553 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Female genital schistosomiasis (FGS) affects up to 56 million women in sub-Saharan Africa and may increase risk of HIV infection. Methods To assess the association of schistosomiasis with HIV infection, peer-reviewed literature published until 31 December 2018 was examined and a pooled estimate for the odds ratio was generated using Bayesian random effects models. Results Of the 364 abstracts that were identified, 26 were included in the summary. Eight reported odds ratios of the association between schistosomiasis and HIV; one reported a transmission hazard ratio of 1.8 (95% CI, 1.2–2.6) among women and 1.4 (95% CI, 1.0–1.9) among men; 11 described the prevalence of schistosomiasis among HIV-positive people (range, 1.5–36.6%); and six reported the prevalence of HIV among people with schistosomiasis (range, 5.8–57.3%). Six studies were selected for quantitative analysis. The pooled estimate for the odds ratio of HIV among people with schistosomiasis was 2.3 (95% CI, 1.2–4.3). Conclusions A significant association of schistosomiasis with HIV was found. However, a specific summary estimate for FGS could not be generated. A research agenda was provided to determine the effect of FGS on HIV infection. The WHO’s policy on mass drug administration for schistosomiasis may prevent HIV.
- Subjects :
- Male
0301 basic medicine
Microbiology (medical)
Female circumcision
medicine.medical_specialty
030106 microbiology
Human immunodeficiency virus (HIV)
HIV Infections
Schistosomiasis
medicine.disease_cause
lcsh:Infectious and parasitic diseases
Association
03 medical and health sciences
0302 clinical medicine
Internal medicine
Prevalence
medicine
Humans
lcsh:RC109-216
030212 general & internal medicine
Mass drug administration
Africa South of the Sahara
Sub-Saharan Africa
business.industry
Transmission (medicine)
Hazard ratio
HIV
Bayes Theorem
General Medicine
Odds ratio
medicine.disease
Infectious Diseases
Meta-analysis
Mass Drug Administration
Female
business
Subjects
Details
- ISSN :
- 12019712
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- International Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....2d6b0ee1906dd967707fb5c9477051e7