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Regulation of filial imprinting and structural plasticity by mTORC1 in newborn chickens
- Source :
- Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Dysregulation of the mechanistic target of rapamycin complex 1 (mTORC1) signaling leads to memory deficits and abnormal social behaviors in adults. However, whether mTORC1 is involved in critical periods of early learning remains largely unexplored. Our study addressed this question by investigating imprinting, a form of learning constrained to a sensitive period that supports filial attachment, in newborn chickens. Imprinting to virtual objects and sounds was assessed after acute manipulations of mTORC1. To further understand the role of mTORC1 during the critical period, structural plasticity was analyzed using DiOlistic labeling of dendritic spines. We found that mTORC1 is required for the emergence of experience-dependent preferences and structural plasticity within brain regions controlling behavior. Furthermore, upon critical period closure, pharmacological activation of the AKT/mTORC1 pathway was sufficient to rescue imprinting across sensory modalities. Thus, our results uncover a novel role of mTORC1 in the formation of imprinted memories and experience-dependent reorganization of neural circuits during a critical period.
- Subjects :
- Telencephalon
0301 basic medicine
Dendritic spine
Dendritic Spines
lcsh:Medicine
Imprinting, Psychological
mTORC1
Mechanistic Target of Rapamycin Complex 1
Biology
Article
03 medical and health sciences
0302 clinical medicine
Stimulus modality
Neuroplasticity
Biological neural network
Animals
Imprinting (psychology)
lcsh:Science
Protein kinase B
Memory Disorders
Neuronal Plasticity
Multidisciplinary
Behavior, Animal
lcsh:R
030104 developmental biology
Animals, Newborn
lcsh:Q
biological phenomena, cell phenomena, and immunity
Chickens
Neuroscience
030217 neurology & neurosurgery
Social behavior
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....2d67e7c1e4285c72cc3bcf3c96a767b5
- Full Text :
- https://doi.org/10.1038/s41598-018-26479-1