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Engineering bionanoparticles for improved biosensing and bioimaging
- Source :
- Current Opinion in Biotechnology. 71:41-48
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The importance of bioimaging and biosensing has been clear with the onset of the COVID-19 pandemic. In addition to viral detection, detection of tumors, glucose levels, and microbes is necessary for improved disease treatment and prevention. Bionanoparticles, such as extracellular vesicles and protein nanoparticles, are ideal platforms for biosensing and bioimaging applications because of their propensity for high density surface functionalization and large loading capacity. Scaffolding large numbers of sensing modules and detection modules onto bionanoparticles allows for enhanced analyte affinity and specificity as well as signal amplification for highly sensitive detection even at low analyte concentrations. Here we demonstrate the potential of bionanoparticles for bioimaging and biosensing by highlighting recent examples in literature that utilize protein nanoparticles and extracellular vesicles to generate highly sensitive detection devices with impressive signal amplification.
- Subjects :
- 0106 biological sciences
0303 health sciences
Analyte
Coronavirus disease 2019 (COVID-19)
SARS-CoV-2
Chemistry
Biomedical Engineering
COVID-19
High density
Nanoparticle
Bioengineering
Nanotechnology
Biosensing Techniques
01 natural sciences
Extracellular vesicles
03 medical and health sciences
010608 biotechnology
Humans
Nanoparticles
Surface modification
Pandemics
Biosensor
Signal amplification
030304 developmental biology
Biotechnology
Subjects
Details
- ISSN :
- 09581669
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Biotechnology
- Accession number :
- edsair.doi.dedup.....2d6514bd99c412c5c2a37620763d053a