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An observational study of surface versus endovascular cooling techniques in cardiac arrest patients: a propensity-matched analysis
- Source :
- Critical Care
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Introduction Various methods and devices have been described for cooling after cardiac arrest, but the ideal cooling method remains unclear. The aim of this study was to compare the neurological outcomes, efficacies and adverse events of surface and endovascular cooling techniques in cardiac arrest patients. Methods We performed a multicenter, retrospective, registry-based study of adult cardiac arrest patients treated with therapeutic hypothermia presenting to 24 hospitals across South Korea from 2007 to 2012. We included patients who received therapeutic hypothermia using overall surface or endovascular cooling devices and compared the neurological outcomes, efficacies and adverse events of both cooling techniques. To adjust for differences in the baseline characteristics of each cooling method, we performed one-to-one matching by the propensity score. Results In total, 803 patients were included in the analysis. Of these patients, 559 underwent surface cooling, and the remaining 244 patients underwent endovascular cooling. In the unmatched cohort, a greater number of adverse events occurred in the surface cooling group. Surface cooling was significantly associated with a poor neurological outcome (cerebral performance category 3–5) at hospital discharge (p = 0.01). After propensity score matching, surface cooling was not associated with poor neurological outcome and hospital mortality [odds ratio (OR): 1.26, 95% confidence interval (CI): 0.81-1.96, p = 0.31 and OR: 0.85, 95% CI: 0.55-1.30, p = 0.44, respectively]. Although surface cooling was associated with an increased incidence of adverse events (such as overcooling, rebound hyperthermia, rewarming related hypoglycemia and hypotension) compared with endovascular cooling, these complications were not associated with surface cooling using hydrogel pads. Conclusions In the overall matched cohort, no significant difference in neurological outcomes and hospital morality was observed between the surface and endovascular cooling methods.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Critical Care and Intensive Care Medicine
Hypothermia, Induced
Republic of Korea
medicine
Humans
Hospital Mortality
Registries
Cardiopulmonary resuscitation
Rewarming
Propensity Score
Adverse effect
Aged
Retrospective Studies
business.industry
Research
Retrospective cohort study
Odds ratio
Middle Aged
Hypothermia
Cardiopulmonary Resuscitation
Confidence interval
Heart Arrest
Surgery
Treatment Outcome
Anesthesia
Propensity score matching
Cohort
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 13648535
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Critical Care
- Accession number :
- edsair.doi.dedup.....2d650b4d5e5996d8c7bbff00c10bd936