Back to Search
Start Over
What makes an allergen?
- Source :
- Clinical & Experimental Allergy. 45:1150-1161
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Allergic diseases are an immune disorder reacting to certain type of allergen(s). Remarkably only a small number of proteins of the plant and animal proteome act as allergens. Therefore, allergens have been clustered according to their common structural, biochemical and functional features. Evidence has accumulated that some allergens possess intrinsic adjuvant properties to stimulate the innate immunity. The adjuvant properties appear to contribute to the allergenicity of the respective proteins, namely the ability to cause allergic sensitization in susceptible subjects or allergic reactions in sensitized individuals. Here, we discuss how allergens interact with the innate immune cells, in particular dendritic cells and epithelial cells, via binding to pattern recognition receptors, exhibiting proteolytic activities and/or inducting type 2 innate lymphoid cells (ILC2), thereby contributing to the sensitization and development of allergic diseases.
- Subjects :
- Antigen Presentation
Innate immune system
medicine.medical_treatment
Immunology
Innate lymphoid cell
Pattern recognition receptor
Antigen-Presenting Cells
Allergens
Biology
medicine.disease_cause
medicine.disease
Epithelium
respiratory tract diseases
Allergic sensitization
Allergen
medicine.anatomical_structure
Hypersensitivity
medicine
Animals
Humans
Immunology and Allergy
Immune disorder
Adjuvant
Sensitization
Subjects
Details
- ISSN :
- 09547894
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Clinical & Experimental Allergy
- Accession number :
- edsair.doi.dedup.....2d5889e755a8dfbf23b385db0928c6d5