Back to Search
Start Over
Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge
- Source :
- Vaccine. 23:3084-3095
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Two recombinant vaccines against Theileria parva, based on a near full-length version of the sporozoite surface antigen p67 (p67 635 ), or an 80 amino acid C-terminal section (p67C), were evaluated by exposure of immunized cattle to natural tick challenge in two sites at the Kenya Coast and one in Central Kenya. Vaccination reduced severe ECF by 47% at the coast and by 52% in central Kenya from an average incidence of 0.53 ± 0.07 (S.E.) in 50 non-immunised controls to an average of 0.27 ± 0.05 in 83 immunised animals. The reduction in severe East Coast fever was similar to that observed in laboratory experiments with p67 635 and p67C. The p67 coding sequence from thirteen T . parva field isolates including seven from vaccinated cattle that were not protected, was 100% identical to the gene on which the recombinant vaccine is based, suggesting a predominantly homologous p67 antigenic challenge. The same parasite isolates were however genetically heterogeneous at several loci other than p67.
- Subjects :
- Protozoan Vaccines
Theileria parva
Protozoan Proteins
Biology
Tick
Polymerase Chain Reaction
Apicomplexa
Ticks
Antigen
parasitic diseases
Animals
Parasite hosting
East Coast fever
Vaccines, Synthetic
General Veterinary
General Immunology and Microbiology
Public Health, Environmental and Occupational Health
Antibodies, Monoclonal
Sequence Analysis, DNA
biology.organism_classification
Virology
Vaccination
Infectious Diseases
Vaccines, Subunit
biology.protein
Molecular Medicine
Cattle
Immunization
Antibody
Microsatellite Repeats
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....2d549193d018a86e80c25293fc2a2310