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Postinfectious Functional Gastrointestinal Disorders in Children: A Multicenter Prospective Study
- Publication Year :
- 2015
-
Abstract
- Objectives To prospectively investigate the occurrence of postinfectious functional gastrointestinal disorders (FGIDs), diagnosed according to the Rome III criteria, in children with acute diarrhea of different infectious etiology. Study design This was a prospective cohort multicenter study. Children 4-17 years of age presenting with acute diarrhea who tested positive for an enteric infection were recruited within 1 month from the episode and matched with control subjects of similar age and sex. Symptoms were evaluated with a validated questionnaire for FGIDs at the time of enrollment in the study and after 3 and 6 months. Results A total of 64 patients (36 boys; median age 5.3 years; age range 4.1-14.1 years) were recruited, 32 subjects in each arm. Infections included rotavirus (56.8%), salmonella (30%), adenovirus (6.6%), norovirus (3.3%), and Giardia lamblia (3.3%). FGIDs were significantly more common in exposed patients compared with controls within 1 month from acute diarrhea (40.6% vs 12.5% [ P = .02, relative risk (RR) = 1.9]), 3 months (53% vs 15.6% [ P = .003, RR = 2.2]), and 6 months (46.8% vs 15.6% [ P = .01, RR = 1.9]) later. No correlation was found between different etiologies, age, or sex, and any type of FGIDs. Among exposed children, abdominal pain–related FGIDs were significantly more frequent compared with controls after 6 months from infection ( P = .04, RR = 1.7). Conclusion This prospective cohort multicenter study supports postinfectious FGIDs as a true entity in children. There seems to be a significant increase in abdominal pain–related FGIDs after acute diarrhea in children within 1 month and 3 and 6 months later.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Gastrointestinal Diseases
medicine.disease_cause
Infections
Gastroenterology
Functional gastrointestinal disorder
Internal medicine
Rotavirus
Surveys and Questionnaires
medicine
Humans
Prospective Studies
Prospective cohort study
Child
Irritable bowel syndrome
business.industry
Incidence (epidemiology)
Incidence
medicine.disease
Relative risk
Child, Preschool
Pediatrics, Perinatology and Child Health
Etiology
Norovirus
Female
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2d4d5a6607920021717473bbdc009dde