Patterns of brain activity during a set-shifting task linked to mild behavioral impairment in Parkinson's disease

Highlights • PD with mild behavioral impairment revealed deficits in cognitive flexibility. • Brain activities during a set-shifting task linked with MBI in PD was evaluated. • PD-MBI revealed reduced activity in the prefrontal and posterior parietal cortices. • The prefrontal activity was associated with cognitive impairment in PD-MBI. • High MBI-C score was associated with reduced deactivation in the hippocampus.
Mild behavioral impairment (MBI) is a neurobehavioral syndrome characterized by later life emergence of sustained neuropsychiatric symptoms, as an at-risk state for incident cognitive decline and dementia. Prior studies have reported that neuropsychiatric symptoms are associated with cognitive abilities in Parkinson’s disease (PD) patients, and we have recently found a strong correlation between MBI and cognitive performance. However, the underlying neural activity patterns of cognitive performance linked to MBI in PD are unknown. Fifty-nine non-demented PD patients and 26 healthy controls were scanned using fMRI during performance of a modified version of the Wisconsin card sorting task. MBI was evaluated using the MBI-checklist, and PD patients were divided into two groups, PD-MBI and PD-noMBI. Compared to the PD-noMBI group and healthy controls, the PD-MBI group revealed less activation in the prefrontal and posterior parietal cortices, and reduced deactivation in the medial temporal region. These results suggest that in PD, MBI reflects deficits in the frontoparietal control network and the hippocampal memory system.