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Gene expression varies within and between enzootic and epizootic lineages of Batrachochytrium dendrobatidis (Bd) in the Americas
- Source :
- Fungal Biology. 124:34-43
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- While much research focus is paid to hypervirulent fungal lineages during emerging infectious disease outbreaks, examining enzootic pathogen isolates can be equally fruitful in delineating infection dynamics and determining pathogenesis. The fungal pathogen of amphibians, Batrachochytrium dendrobatidis (Bd), exhibits markedly different patterns of disease in natural populations, where it has caused massive amphibian declines in some regions, yet persists enzootically in others. Here we compare in vitro gene expression profiles of a panel of Bd isolates representing both the enzootic Bd-Brazil lineage, and the more recently diverged, panzootic lineage, Bd-GPL. We document significantly different lineage-specific and intralineage gene expression patterns, with Bd-Brazil upregulating genes with aspartic-type peptidase activity, and Bd-GPL upregulating CBM18 chitin-binding genes, among others. We also find pronounced intralineage variation in membrane integrity and transmembrane transport ability within our Bd-GPL isolates. Finally, we highlight unexpectedly divergent expression profiles in sympatric panzootic isolates, underscoring microgeographic functional variation in a largely clonal lineage. This variation in gene expression likely plays an important role in the relative pathogenesis and host range of Bd-Brazil and Bd-GPL isolates. Together, our results demonstrate that functional genomics approaches can provide information relevant to studies of virulence evolution within the Bd clade.
- Subjects :
- Batrachochytrium
0106 biological sciences
Lineage (genetic)
Genes, Fungal
Biology
01 natural sciences
Amphibians
03 medical and health sciences
Genetics
medicine
Animals
Chytridiomycosis
Gene
Phylogeny
Ecology, Evolution, Behavior and Systematics
Panzootic
Epizootic
030304 developmental biology
0303 health sciences
Genetic Variation
medicine.disease
Sympatry
Infectious Diseases
Mycoses
Emerging infectious disease
Enzootic
Americas
Transcriptome
Functional genomics
Brazil
010606 plant biology & botany
Subjects
Details
- ISSN :
- 18786146
- Volume :
- 124
- Database :
- OpenAIRE
- Journal :
- Fungal Biology
- Accession number :
- edsair.doi.dedup.....2d38e8aa8af576a0ea1923a0a1279efa