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The loss of infrared-light sensitivity of photoreceptor cells measured with two-photon excitation as an indicator of diabetic retinopathy
- Source :
- Retina (Philadelphia, Pa.)
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Supplemental Digital Content is Available in the Text. Infrared light two-photon excitation provides a new parameter for testing visual function, one that can be used in the detection and monitoring of ocular abnormality. Diabetic retinopathy significantly impairs retinal sensitivity to infrared light.<br />Purpose: Human photoreceptors are sensitive to infrared light (IR). This sensitivity can be used as a novel indicator of retinal function. Diabetic retinopathy patients were assessed using in vivo two-photon excitation and compared their scotopic IR threshold with that of healthy patients. Methods: Sixty-two participants, 28 healthy and 34 with diabetic retinopathy, underwent a comprehensive eye examination, where visual acuity and contrast sensitivity were assessed. Infrared thresholds were measured in the fovea and parafovea following 30-minute dark adaptation. A two-photon excitation device was used with integrated pulsed laser light (1,045 nm) for sensitivity testing and scanning laser ophthalmoscopy for fundus imaging. Results: The mean Snellen visual acuity of diabetic patients (6/7.7) was worse than that of the healthy patients (6/5.5), which was significantly different (P < 0.001). Disease patients had decreased contrast sensitivity, especially at 6 and 18 cycles/degree. The mean retinal sensitivity to IR light in eyes with diabetic retinopathy (11.6 ± 2.0 dB) was significantly (P < 0.001) lower than that in normal eyes (15.5 ± 1.3 dB). Conclusion: Compared with healthy control subjects, the IR light sensitivity of diabetic patients was significantly impaired. Two-photon measurements can be used in the assessment of retinal disease, but further studies are needed to validate IR light stimulation in various stages of diabetic retinopathy.
- Subjects :
- Male
Fovea Centralis
medicine.medical_specialty
Visual acuity
infrared vision
genetic structures
Infrared Rays
media_common.quotation_subject
Visual Acuity
Dark Adaptation
Pilot Projects
030209 endocrinology & metabolism
Fundus (eye)
retinal sensitivity
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Photophobia
Ophthalmology
visual function
medicine
Humans
Contrast (vision)
Original Study
Photoreceptor Cells
Scotopic vision
media_common
two-photon excitation
Diabetic Retinopathy
diabetes
Light sensitivity
business.industry
Retinal
General Medicine
Diabetic retinopathy
Middle Aged
medicine.disease
Scanning laser ophthalmoscopy
Ophthalmoscopy
chemistry
030221 ophthalmology & optometry
Visual Field Tests
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 0275004X
- Database :
- OpenAIRE
- Journal :
- Retina
- Accession number :
- edsair.doi.dedup.....2d34cf52d49736f392567d9d194135af