Back to Search
Start Over
Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu(7)) mRNA levels in two animal models of depression
- Source :
- Neuroscience Letters; Vol 482
- Publication Year :
- 2010
- Publisher :
- ELSEVIER IRELAND LTD, 2010.
-
Abstract
- There is increasing evidence to suggest that metabotropic glutamate (mGlu) receptors including mGlu(7) receptor are important in the pathophysiology of stress-related psychiatric disorders such as anxiety and major depression. mGlu(7) receptor is highly expressed in the hippocampus, a key region involved in the modulation of depression-related behaviour. Moreover, mice deficient in mGlu(7) receptor have an antidepressant-like behaviour and altered stress response. To our knowledge there is little information as to whether stressful phenotypes can influence hippocampal mGlu(7) receptor levels. To this end, we examined hippocampal mGlu(7) receptor mRNA expression in two models of depression, the stress-sensitive Wistar Kyoto (WKY) and the maternally separated model of early-life stress. In situ hybridization analysis revealed that the WKY, but not the maternally separated (MS) rats displayed selective increases in mGlu(7) receptor mRNA expression in subregions of the hippocampus compared to relevant controls. These data suggest that higher levels of this receptor could affect the behaviour in response to stressful conditions and may play a role in WKY animal's susceptibility to stress-related disorders. However, the data in maternally separated animals confirm that whilst hippocampal mGlu(7) receptors maybe involved in certain aspects of stress biology, an increased expression is not necessary for the manifestation of depression-related phenotype per se.
- Subjects :
- Male
medicine.medical_specialty
Hippocampus
Hippocampal formation
Biology
Receptors, Metabotropic Glutamate
Rats, Inbred WKY
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Species Specificity
Internal medicine
Animal models of depression
medicine
Animals
RNA, Messenger
Receptor
Neurotransmitter
030304 developmental biology
0303 health sciences
Depression
Maternal Deprivation
General Neuroscience
Metabotropic glutamate receptor 7
Glutamate receptor
Rats
Disease Models, Animal
Endocrinology
Metabotropic receptor
chemistry
Stress, Psychological
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 482
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....2d283aea90efd4753362a88954d45438
- Full Text :
- https://doi.org/10.1016/j.neulet.2010.07.018