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Towards spatio-temporally resolved developmental cardiac gene regulatory networks in zebrafish
- Source :
- Briefings in Functional Genomics.
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Heart formation in the zebrafish involves a rapid, complex series of morphogenetic events in three-dimensional space that spans cardiac lineage specification through to chamber formation and maturation. This process is tightly orchestrated by a cardiac gene regulatory network (GRN), which ensures the precise spatio-temporal deployment of genes critical for heart formation. Alterations of the timing or spatial localisation of gene expression can have a significant impact in cardiac ontogeny and may lead to heart malformations. Hence, a better understanding of the cellular and molecular basis of congenital heart disease relies on understanding the behaviour of cardiac GRNs with precise spatiotemporal resolution. Here, we review the recent technical advances that have expanded our capacity to interrogate the cardiac GRN in zebrafish. In particular, we focus on studies utilising high-throughput technologies to systematically dissect gene expression patterns, both temporally and spatially during heart development.
- Subjects :
- 0303 health sciences
Heart disease
Heart development
biology
Heart malformation
Gene regulatory network
General Medicine
medicine.disease
biology.organism_classification
Biochemistry
03 medical and health sciences
0302 clinical medicine
Gene expression
Genetics
medicine
Heart formation
Molecular Biology
Neuroscience
Gene
Zebrafish
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- ISSN :
- 20412657 and 20412649
- Database :
- OpenAIRE
- Journal :
- Briefings in Functional Genomics
- Accession number :
- edsair.doi.dedup.....2d2603ebae5d237f427853176a8c8343