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Role of estrogen treatment in the management of schizophrenia
- Source :
- CNS drugs. 26(7)
- Publication Year :
- 2012
-
Abstract
- Increasing evidence from epidemiological, preclinical and clinical studies suggests that estrogens may exert psychoprotective effects in schizophrenia. Observations of gender differences in the onset and course of schizophrenia have prompted exploration of the effects of estrogen on the CNS. The aim of this paper is to provide an overview of different applications of adjunctive estrogen as a possible treatment for symptoms of schizophrenia in both men and women. Recent trials have suggested that estrogen augmentation therapy may be able to enhance the management of schizophrenia; however, the clinical application of estrogen as a treatment has been limited by potential side effects, the most worrying being breast and uterine cancer in women, and feminization in men. Selective estrogen receptor modulators (SERMs), however, may offer therapeutic benefits for both men and women with schizophrenia without posing threat to breast and uterine tissue and without feminizing effects. The use of estrogen opens up new possibilities for both men and women in the treatment of severe mental illnesses such as schizophrenia. With further preclinical and clinical research, it is hoped that this promising field of hormone modulation can continue to evolve and eventually be translated into real therapeutic potential.
- Subjects :
- Male
Selective Estrogen Receptor Modulators
medicine.medical_specialty
medicine.drug_class
Feminization (biology)
Bioinformatics
Sex Factors
Management of schizophrenia
Uterine cancer
medicine
Animals
Humans
Pharmacology (medical)
Psychiatry
business.industry
Estrogens
medicine.disease
Psychiatry and Mental health
Clinical research
Estrogen
Selective estrogen receptor modulator
Schizophrenia
Female
Neurology (clinical)
Psychopharmacology
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 11791934
- Volume :
- 26
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- CNS drugs
- Accession number :
- edsair.doi.dedup.....2d2428a7f308f0e5bc6ed4b558f1844f