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Sericea lespedeza (Lespedeza cuneata) whole plant extract enhances rat muscle mass and sperm production by increasing the activity of NO-cGMP pathway and serum testosterone
- Source :
- Tropical Journal of Pharmaceutical Research; Vol. 20 No. 1 (2021); 121-128
- Publication Year :
- 2021
- Publisher :
- Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria, 2021.
-
Abstract
- Purpose: To analyze the effects of an aqueous extract of Sericea lespedeza (SL) on rat male menopause.Methods: Levels of nitric oxide (NO), endothelial nitric oxide synthase (NOS), cGMP, and prostaglandin E2 (PGE2) in the penile corpus cavernosum of the rats were evaluated using appropriate kits. Serum levels of dihydrotestosterone (DHT), testosterone, sex hormone-binding globulin (SHBG), and 17-beta hydroxysteroid dehydrogenases (17β-HSD) were measured with enzyme-linked immunosorbent assay kits. Total and motile sperms were counted on a hemocytometer. Histological changes in rat testis and epididymis were analyzed with hematoxylin and eosin staining.Results: The levels of NO, NOS, and cGMP (but not PGE2) increased in a dose-dependent manner (p< 0.05) upon administration of an aqueous extract of SL (AESL), while levels of DHT, 17β-HSD, and testosterone increased in the group administered with 300 mg/kg of AESL. Epididymal sperm count increased by 24 % in such rats compared to controls (p < 0.05).Conclusion: The aqueous extract of SL improves sperm count and muscle mass in rats by increasing the levels of NO, NOS, cGMP and testosterone. Thus, SL extract can potentially be developed as an alternative therapeutic agent for clinical management of TDS. Keywords: NO-cGMP, Testosterone, Hormones, Sperm count, Muscle mass, Sericea lespedeza, Lespedeza cuneata
- Subjects :
- medicine.medical_specialty
endocrine system
Lespedeza cuneata
biology
Pharmaceutical Science
Lespedeza
NO-cGMP, Testosterone, Hormones, Sperm count, Muscle mass, Sericea lespedeza, Lespedeza cuneata
biology.organism_classification
Epididymis
Sperm
Nitric oxide
chemistry.chemical_compound
Endocrinology
medicine.anatomical_structure
chemistry
Dihydrotestosterone
Internal medicine
medicine
Pharmacology (medical)
Spermatogenesis
Testosterone
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 15965996 and 15969827
- Database :
- OpenAIRE
- Journal :
- Tropical Journal of Pharmaceutical Research
- Accession number :
- edsair.doi.dedup.....2d213d9e796010356591cfcd3d7ffad5