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MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma
- Source :
- FEBS Letters. (24):4362-4370
- Publisher :
- Federation of European Biochemical Societies. Published by Elsevier B.V.
-
Abstract
- We previously showed that high expression levels of SOX9 correlate with hepatocellular carcinoma (HCC) progression. However, the exact role that SOX9 plays in HCC remains unclear. In this study, we firstly confirmed that miRNA-101 directly targets SOX9 in HCC. Ectopic expression of miR-101 significantly inhibited HCC cell proliferation and tumorigenicity by targeting SOX9. Moreover, the down-regulation of miR-101 in clinical HCC tissues correlates with tumor aggressiveness and poor prognosis. Therefore, miR-101 may suppress HCC tumor progression by down-regulating SOX9. MiR-101 may be a potential prognostic marker and therapeutic target for HCC.
- Subjects :
- Male
endocrine system
Carcinoma, Hepatocellular
Hepatocellular carcinoma
Disease-free survival
Biophysics
SOX9
Favorable prognosis
Biochemistry
stomatognathic system
Structural Biology
microRNA
Genetics
Carcinoma
medicine
Humans
Overall survival
MicroRNA-101
Molecular Biology
neoplasms
Cell Proliferation
Cell growth
business.industry
Clinicopathological feature
Liver Neoplasms
SOX9 Transcription Factor
Cell Biology
Hep G2 Cells
Middle Aged
medicine.disease
digestive system diseases
MicroRNAs
Cell Transformation, Neoplastic
Tumor progression
embryonic structures
Cancer research
Ectopic expression
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Issue :
- 24
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....2d206a5f846f3b4ef549d1431dffa754
- Full Text :
- https://doi.org/10.1016/j.febslet.2012.10.053