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Obesity, COVID-19 and innate immunometabolism
- Source :
- British Journal of Nutrition, The British Journal of Nutrition
- Publication Year :
- 2020
- Publisher :
- Cambridge University Press (CUP), 2020.
-
Abstract
- As COVID-19 continues to spread worldwide, severe disease and mortality have been observed in obese patients. We discuss how obesity and obesity-associated factors such as ‘meta-flammation’, dietary fat intake and paradoxical suppression of the innate immune response within the pulmonary compartment may be crucial determinants in the host response to a novel viral pathogen. Modulation of immune cell bioenergetics and metabolic potential plays a central role in the innate immune response to infection, and as we strive to combat this new global health threat, immunometabolism of the innate immune system warrants attention.
- Subjects :
- 0301 basic medicine
Coronavirus disease 2019 (COVID-19)
Respiratory System
Severe disease
Medicine (miscellaneous)
Inflammation
03 medical and health sciences
Eating
0302 clinical medicine
Immune system
Metabolic potential
medicine
Global health
Humans
Obesity
Innate immune system
Immunometabolism
Nutrition and Dietetics
business.industry
SARS-CoV-2
COVID-19
Full Papers
medicine.disease
Dietary Fats
Immunity, Innate
030104 developmental biology
Immune System
Immunology
Molecular Nutrition
medicine.symptom
business
Energy Metabolism
IL-1β inflammation
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 14752662 and 00071145
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....2d161b40a3d4b15212979ce24811cf53
- Full Text :
- https://doi.org/10.1017/s0007114520003529