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Regulation of CaV2 calcium channels by G protein coupled receptors
- Source :
- Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828(7):1629-1643
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of physiological responses. This review focuses on the inhibition of CaV2 (N- and P/Q-type) Ca2+-channels by G protein coupled receptors (GPCRs), which exerts important autocrine/paracrine control over synaptic transmission and neuroendocrine secretion. Voltage-dependent inhibition is the most widespread mechanism, and involves direct binding of the G protein βγ dimer (Gβγ) to the α1 subunit of CaV2 channels. GPCRs can also recruit several other distinct mechanisms including phosphorylation, lipid signaling pathways, and channel trafficking that result in voltage-independent inhibition. Current knowledge of Gβγ-mediated inhibition is reviewed, including the molecular interactions involved, determinants of voltage-dependence, and crosstalk with other cell signaling pathways. A summary of recent developments in understanding the voltage-independent mechanisms prominent in sympathetic and sensory neurons is also included. This article is part of a Special Issue entitled: Calcium channels.
- Subjects :
- Biophysics
G protein coupled receptor
N-type calcium channel
Biology
Biochemistry
Article
Receptors, G-Protein-Coupled
03 medical and health sciences
0302 clinical medicine
Calcium Channels, N-Type
Heterotrimeric G protein
Animals
Humans
Calcium Signaling
Tyrosine kinase
030304 developmental biology
Calcium signaling
G protein-coupled receptor
0303 health sciences
Calcium channel
T-type calcium channel
Cell Biology
Cell biology
R-type calcium channel
G beta-gamma complex
PiP2
Arachidonic acid
Calcium
Gβγ
Ion Channel Gating
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00052736
- Volume :
- 1828
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Accession number :
- edsair.doi.dedup.....2d0973bb726cb712b2fbd5c16c9f5d7b
- Full Text :
- https://doi.org/10.1016/j.bbamem.2012.10.004