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Protecting the Protectors: Reducing the Biological Toxicity of UV Sunscreens by Zeolite Encapsulation
- Source :
- Photochemistry and Photobiology. 82:1606-1611
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- The phototoxic and photoallergic effects of the once popular UV sunscreen p-aminobanzoic acid are related, in part, to its ability to sensitize the formation of singlet oxygen as well as other reactive oxygen species. In this work we demonstrate that the sunscreen-photoinduced inactivation of a model protein, horseradish peroxidase, is reduced by approximately a factor of three when the sunscreen is encaspsulated in zeolite sodium Y. These results provide evidence that using the technology of zeolite encapsulation to prepare a supramolecular sunscreen that minimizes the skin contact of active ingredients may reduce the adverse effects of "naked" sunscreens on biological systems. These radiation-induced effects, unfortunately, frequently accompany the desirable UV-screening role of these products. These results provide an important benchmark for the use of zeolite encapsulation as a means of improving the safety of UV sunscreens for topical application.
- Subjects :
- Active ingredient
chemistry.chemical_classification
Reactive oxygen species
Ultraviolet Rays
Chemistry
Singlet oxygen
Model protein
Capsules
Skin contact
General Medicine
Photochemistry
Biochemistry
chemistry.chemical_compound
Spectrophotometry
Toxicity
Zeolites
Spectrophotometry, Ultraviolet
Physical and Theoretical Chemistry
Phototoxicity
Zeolite
4-Aminobenzoic Acid
Drug Antagonism
Sunscreening Agents
Subjects
Details
- ISSN :
- 17511097 and 00318655
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Photochemistry and Photobiology
- Accession number :
- edsair.doi.dedup.....2d092238ee71d520ea84df1508e419b3