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Differential modulation of MHC class I antigen expression on mouse brain endothelial cells by MHV-4 infection

Authors :
Michael N. Hart
R.L. Knobler
Jeymohan Joseph
F.D. Lubli
Source :
Journal of Neuroimmunology
Publication Year :
1989

Abstract

Virus-induced modulation of mouse cerebral endothelial cell class I and class II antigens by the neurotropic coronavirus, MHV-4 (JHM), was examined by flow cytometry. In susceptible BALB/c, H-2Kd was downregulated, while H-2Dd was upregulated following infection by MHV-4. In contrast, H-2K and H-2D antigens were both upregulated in either MHV-4-susceptible B10.S and (BALB/c x SJL) F1, or MHV-4-resistant SJL-derived cerebral endothelial cells following infection with this virus. Class II antigen expression was unchanged following MHV-4 infection. Virus-induced MHC class I modulation is genetically regulated, and may influence virus clearance by class I-dependent CTL.

Details

ISSN :
01655728
Volume :
22
Issue :
3
Database :
OpenAIRE
Journal :
Journal of neuroimmunology
Accession number :
edsair.doi.dedup.....2d07e1066bf1288e59a9ce4e8c192b20