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Differential modulation of MHC class I antigen expression on mouse brain endothelial cells by MHV-4 infection
- Source :
- Journal of Neuroimmunology
- Publication Year :
- 1989
-
Abstract
- Virus-induced modulation of mouse cerebral endothelial cell class I and class II antigens by the neurotropic coronavirus, MHV-4 (JHM), was examined by flow cytometry. In susceptible BALB/c, H-2Kd was downregulated, while H-2Dd was upregulated following infection by MHV-4. In contrast, H-2K and H-2D antigens were both upregulated in either MHV-4-susceptible B10.S and (BALB/c x SJL) F1, or MHV-4-resistant SJL-derived cerebral endothelial cells following infection with this virus. Class II antigen expression was unchanged following MHV-4 infection. Virus-induced MHC class I modulation is genetically regulated, and may influence virus clearance by class I-dependent CTL.
- Subjects :
- viruses
Immunology
Clinical Neurology
Mice, Inbred Strains
medicine.disease_cause
Virus
Article
Mice
Antigen
MHC class I
medicine
Immunology and Allergy
Animals
Endothelium
Cells, Cultured
Coronavirus
Murine hepatitis virus
biology
MHC class I antigen
Histocompatibility Antigens Class I
virus diseases
Brain
Flow Cytometry
Virology
Endothelial stem cell
CTL
Neurology
Cell culture
Hepatitis, Viral, Animal
biology.protein
Neurology (clinical)
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 22
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of neuroimmunology
- Accession number :
- edsair.doi.dedup.....2d07e1066bf1288e59a9ce4e8c192b20