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Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex
- Source :
- Journal of Neuroscience, Journal of Neuroscience; Vol 33
- Publication Year :
- 2013
- Publisher :
- Society for Neuroscience, 2013.
-
Abstract
- Perineuronal nets are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites, and are involved in the control of brain plasticity and the closure of critical periods. Expression of the link protein Crtl1/Hapln1 in neurons has recently been identified as the key event triggering the formation of perineuronal nets. Here we show that the genetic attenuation of perineuronal nets in adult brain Crtl1 knockout mice enhances long term object recognition memory and facilitates long-term depression in the perirhinal cortex, a neural correlate of object recognition memory. Identical prolongation of memory follows localised digestion of perineuronal nets with chondroitinase ABC, an enzyme that degrades the chondroitin sulphate proteoglycans (CSPGs) components of PNNs. The memory-enhancing effect of chondroitinase ABC treatment attenuated over time, suggesting that regeneration of PNNs gradually restored control plasticity levels. Our findings indicate that perineuronal nets regulate both memory and experience-driven synaptic plasticity in adulthood.
- Subjects :
- Male
Time Factors
Chondroitin ABC Lyase
Transgenic
Mice
chemistry.chemical_compound
0302 clinical medicine
Perirhinal cortex
Long-term depression
Long-Term Synaptic Depression
Inbred BALB C
Neurons
Cerebral Cortex
Extracellular Matrix Proteins
Mice, Inbred BALB C
0303 health sciences
General Neuroscience
Perineuronal net
Extracellular Matrix Protein
Penicillinase
Extracellular Matrix
medicine.anatomical_structure
Proteoglycans
Psychology
Genotype
Time Factor
Mice, Transgenic
Recognition (Psychology)
Article
03 medical and health sciences
Neuroplasticity
medicine
Animals
030304 developmental biology
Recognition memory
Analysis of Variance
Neuroscience (all)
Animal
Excitatory Postsynaptic Potentials
Recognition, Psychology
Neuron
Newborn
Electric Stimulation
Animals, Newborn
Excitatory Postsynaptic Potential
chemistry
Chondroitin sulfate proteoglycan
Proteoglycan
Synaptic plasticity
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....2cfd145d1e820179c682fdeb351350a2