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Bazedoxifene enhances paclitaxel efficacy to suppress glioblastoma via altering Hippo/YAP pathway
- Source :
- Journal of Cancer
- Publication Year :
- 2020
- Publisher :
- Ivyspring International Publisher, 2020.
-
Abstract
- Glioblastoma multiform (GBM) is an aggressive type of brain tumor originated from astrocytes. Owing to the limited therapeutic options, intensive efforts are still being made to find novel treatments for GBM. In this study, we first identified that bazedoxifene bore the ability to reduce cell survival and cell invasion of glioblastoma cells. Furthermore, our results also revealed that bazedoxifene combining with paclitaxel had better efficacy to suppress glioblastoma progression by promoting apoptosis and reducing EMT. Combination of bazedoxifene and paclitaxel also accelerated YAP phosphorylation and inactivation. Importantly, preclinical animal model also verified our in vitro findings. Together, our data not only define the underlying mechanism responsible for action of bazedoxifene on glioblastoma cells but also build strong rational to develop bazedoxifene for the treatment of GBM patients.
- Subjects :
- 0301 basic medicine
Paclitaxel
Brain tumor
Bazedoxifene
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Cell invasion
business.industry
medicine.disease
In vitro
nervous system diseases
030104 developmental biology
Oncology
chemistry
Apoptosis
030220 oncology & carcinogenesis
Cancer research
Phosphorylation
YAP
Glioblastoma
business
Research Paper
medicine.drug
Subjects
Details
- ISSN :
- 18379664
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer
- Accession number :
- edsair.doi.dedup.....2cf84370d6e2d9a0b762a586756864d3