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Characterisation of EFV12 a bio-active small peptide produced by the human intestinal isolate Lactobacillus gasseri SF1109
- Publication Year :
- 2020
-
Abstract
- EFV12 is a small bioactive peptide produced by Lactobacillus gasseri SF1109, a human intestinal isolate with probiotic features. In this study, EFV12 antimicrobial and anti-inflammatory properties are characterised. In particular, we propose a possible mechanism of action for EFV12 involving bacterial membranes targeting. Moreover, we show that this small peptide is able to bind lipopolysaccharides (LPS) and to counteract its inflammatory insult preventing LPS action on Toll-like receptor 4, thus interfering with extracellular signal-regulated kinase, p38 and Jun N-terminal kinase, mitogen-activated protein kinases signalling pathways. Altogether these observations suggest that the bioactive peptide EFV12 is a good candidate to promote L. gasseri induced gut homeostasis and counteracting intestinal pathogens.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
p38 mitogen-activated protein kinases
Lactobacillus gasseri
01 natural sciences
Microbiology
law.invention
03 medical and health sciences
Probiotic
law
medicine
Extracellular
Receptor
biology
010405 organic chemistry
Kinase
Chemistry
Antimicrobial
biology.organism_classification
0104 chemical sciences
030104 developmental biology
Mechanism of action
Biochemistry
medicine.symptom
LPS binding
Antimicrobial peptide
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2cc0d75042e4de507180512ae26b96a3