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The Risk of Nephropathy, Retinopathy, and Leg Amputation in Patients With Diabetes and Hypertension: A Nationwide, Population-Based Retrospective Cohort Study
- Source :
- Frontiers in Endocrinology, Frontiers in Endocrinology, Vol 12 (2021)
- Publication Year :
- 2021
-
Abstract
- PurposeTo compare the risks of chronic kidney disease (CKD), end-stage renal disease (ESRD), sight-threatening retinopathy, and leg amputation between patients with diabetes or hypertension.MethodsFrom January 1, 2000, to December 31, 2015, we identified 28943 matched pairs of patients with diabetes with and without subsequent hypertension, 89102 pairs of patients with hypertension with and without subsequent diabetes, and 145294 pairs of patients with coexisting diabetes and hypertension with a previous history of diabetes or hypertension from Taiwan’s National Health Insurance Research Database. Cox proportional-hazard models were used for calculating the risks of CKD, sight-threatening retinopathy, and leg amputation.ResultsThe mean follow-up time of this study in different cohorts was between 3.59 and 4.28 years. In diabetes patients with vs. without subsequent hypertension, hypertension patients with vs. without subsequent diabetes, and comorbid diabetes and hypertension patients with previous diabetes vs. with previous hypertension, the adjusted HRs (95% CIs) for CKD were 2.77 (2.61-2.94), 1.73 (1.68-1.77), and 1.04 (1.02-1.07); for ESRD were 42.38 (22.62-79.4), 2.76 (2.43-3.13), and 0.72 (0.66-0.79); for sight-threatening retinopathy were 2.07 (1.85-2.3), 3.41 (3.14-3.71), and for leg amputation were 1.51 (1.43-1.58); and 4.74 (3.02-7.43), 6.27(4.72-8.31), and 1.19(1.03-1.38).ConclusionsThis study demonstrated that both diabetes and hypertension are risk factors for the development of CKD, retinopathy, and amputation. Tracing subsequent diabetes for patients with hypertension, and hypertension for patients with diabetes are important in clinical settings.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Taiwan
Risk Assessment
Diseases of the endocrine glands. Clinical endocrinology
Amputation, Surgical
End stage renal disease
Nephropathy
Young Adult
Endocrinology
Diabetes mellitus
Internal medicine
medicine
Humans
Diabetic Nephropathies
leg amputation
Aged
Retrospective Studies
Original Research
Aged, 80 and over
Diabetic Retinopathy
end-stage renal disease
business.industry
Retrospective cohort study
Middle Aged
RC648-665
medicine.disease
diabetes and hypertension
Cohort
Hypertension
Kidney Failure, Chronic
sight-threatening retinopathy
Female
business
chronic kidney disease
Retinopathy
Kidney disease
Cohort study
Subjects
Details
- ISSN :
- 16642392
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in endocrinology
- Accession number :
- edsair.doi.dedup.....2cbf99b3003a1f5773d7a03b4065371d